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Elemental analysis of atherosclerotic plaque by ICP-MS and LA-ICP-MS

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dc.abstract.enAtherosclerosis can be described as narrowing the lumen of an artery due to the build-up of plaque. Chemical composition of an atherosclerotic plaque strongly depends on its clinically important stability. The aim of a study was elemental analysis of atherosclerotic plaque by using inductively coupled plasma mass spectrometry (ICP-MS) and creating the elemental distribution maps by using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Elements such as Li, Mg, Ca, V, Mn, Fe, Co, Cu, As, Se, Rb, Sr, Ag, Cd, Pb were successfully quantified, with the greatest content of typical calcification components: Ca and Mg. LA-ICP-MS analysis was performed with no need of sample mineralization. Inhomogeneous distribution of several elements was observed, again mainly in case of calcification (Ca, Mg, Sr, P). Moreover, the influence of sample preparation was stated. Lyophilisation enhanced analytes concentration, but also caused the loss of several elements, such as Pb or S.
dc.affiliationUniwersytet Warszawski
dc.conference.countryCzechy
dc.conference.datefinish2018-09-21
dc.conference.datestart2018-09-20
dc.conference.placePraga
dc.conference.seriesInternational Students Conference "Modern Analytical Chemistry"
dc.conference.seriesInternational Students Conference "Modern Analytical Chemistry"
dc.conference.seriesweblinkhttps://web.natur.cuni.cz/analchem/isc-mac/
dc.conference.shortcut14th International Students Conference Modern Analytical Chemistry
dc.conference.weblinkhttp://web.natur.cuni.cz/analchem/isc/isc14.pdf
dc.contributor.authorToczyłowska, Beata
dc.contributor.authorRuszczyńska, Anna
dc.contributor.authorWagner, Barbara
dc.contributor.authorBulska, Ewa
dc.contributor.authorZiemińska, Elżbieta
dc.contributor.authorJakuczun, Wawrzyniec
dc.contributor.authorSzostek, Małgorzata
dc.contributor.authorJagielska, Agata
dc.contributor.authorGawor, Andrzej
dc.date.accessioned2024-01-24T22:46:17Z
dc.date.available2024-01-24T22:46:17Z
dc.date.issued2018
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.versionFINAL_PUBLISHED
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/106036
dc.identifier.weblinkhttp://web.natur.cuni.cz/analchem/isc/isc14.pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.pages44-50
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleElemental analysis of atherosclerotic plaque by ICP-MS and LA-ICP-MS
dc.typeJournalArticle
dspace.entity.typePublication