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Activation-induced chromatin reorganization in neurons depends on HDAC1 activity

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dc.abstract.enSpatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that stimulation of neurons causes condensation of large chromatin domains. This phenomenon can be observed in vitro in cultured rat hippocampal neurons as well as in vivo in the amygdala and hippocampal neurons. Activity-induced chromatin condensation is an active, rapid, energy-dependent, and reversible process. It involves calcium-dependent pathways but is independent of active transcription. It is accompanied by the redistribution of posttranslational histone modifications and rearrangements in the spatial organization of chromosome territories. Moreover, it leads to the reorganization of nuclear speckles and active domains located in their proximity. Finally, we find that the histone deacetylase HDAC1 is the key regulator of this process. Our results suggest that HDAC1-dependent chromatin reorganization constitutes an important level of transcriptional regulation in neurons.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorPlewczyński, Dariusz
dc.contributor.authorMAGALSKA, ADRIANA
dc.contributor.authorWilczyński, Grzegorz
dc.contributor.authorŚLIWIŃSKA, MAŁGORZATA
dc.contributor.authorBERNAŚ, TYTUS
dc.contributor.authorGONZALEZ, ANA MARTIN
dc.contributor.authorGIELNIEWSKI, BARTŁOMIEJ
dc.contributor.authorKrawczyk, Katarzyna
dc.contributor.authorHolm, Dagmara
dc.contributor.authorWojtaś, Bartosz
dc.contributor.authorYUSHKEVICH, YANA
dc.contributor.authorCzaban, Iwona
dc.contributor.authorGrabowska, Agnieszka
dc.contributor.authorSzczepankiewicz, Andrzej
dc.contributor.authorBokota, Grzegorz
dc.contributor.authorBramham, Clive R.
dc.contributor.authorKanhema, Tambudzai
dc.contributor.authorOlszyński, Krzysztof
dc.contributor.authorFilipkowski, Robert
dc.contributor.authorTrzaskoma, Pawel
dc.contributor.authorJanuszewicz, Elzbieta
dc.contributor.authorSas-Nowosielska, Hanna
dc.date.accessioned2024-01-24T15:37:54Z
dc.date.available2024-01-24T15:37:54Z
dc.date.copyright2022-02-15
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number7
dc.description.versionFINAL_PUBLISHED
dc.description.volume38
dc.identifier.doi10.1016/J.CELREP.2022.110352
dc.identifier.issn2211-1247
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/100202
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S2211124722000687
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofCell Reports
dc.relation.pages110352
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.subject.enchromatin organization
dc.subject.enchromatin condensation
dc.subject.enneuronal activation
dc.subject.enepigenetics
dc.subject.ennuclear bodies
dc.subject.enHDAC1
dc.titleActivation-induced chromatin reorganization in neurons depends on HDAC1 activity
dc.typeJournalArticle
dspace.entity.typePublication