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Synthesis and evaluation of biological properties of ferrocenyl-podophyllotoxin conjugates

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dc.abstract.enThree types, esters, amides and 1,2,3-triazoles, of ferrocenyl–podophyllotoxin conjugates were synthesised, and their anticancer activity was evaluated. We observed that the most potent ferrocenyl derivatives were esters. Esters 15, 16 and 17 acted in a similar way to podophyllotoxin, i.e. reduced the number of G1 phase cells and induced G2/M blockage, while esters 14 and 18 and amide 19 blocked cells in S phase in a similar manner to etoposide.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBłauż, Andrzej
dc.contributor.authorPlażuk, Damian
dc.contributor.authorWieczorek-Błauż, Anna
dc.contributor.authorRychlik, Błażej
dc.contributor.authorMakal, Anna
dc.date.accessioned2024-01-26T09:26:26Z
dc.date.available2024-01-26T09:26:26Z
dc.date.copyright2017-07-14
dc.date.issued2017
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number33
dc.description.versionFINAL_PUBLISHED
dc.description.volume46
dc.identifier.doi10.1039/C7DT02107K
dc.identifier.issn1477-9226
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121283
dc.identifier.weblinkhttp://pubs.rsc.org/en/Content/ArticleLanding/2017/DT/C7DT02107K
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofDalton Transactions
dc.relation.pages10847-10858
dc.rightsCC-BY-NC
dc.sciencecloudnosend
dc.subject.en1,2,3-riazoles
dc.subject.enanticancer activities
dc.subject.enbiological properties
dc.subject.enetoposide
dc.subject.enferrocene
dc.subject.enferrocenyl derivatives
dc.subject.enpodophyllotixin
dc.subject.pl1,2,3-triazole
dc.subject.plaktywność przeciwnowotworowa
dc.subject.plwłaściwości biologiczne
dc.subject.pletopozyd
dc.subject.plferrocen
dc.subject.plferrocenylowe pochodne
dc.subject.plpodofilotoksyna
dc.titleSynthesis and evaluation of biological properties of ferrocenyl-podophyllotoxin conjugates
dc.typeJournalArticle
dspace.entity.typePublication