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Design of therapeutic self-assembled monolayers of thiolated abiraterone

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cris.lastimport.scopus2024-02-12T19:43:36Z
dc.abstract.enThe aim of our work was to synthetize of a new analogue of abiraterone—thiolated abiraterone (HS-AB) and design a gold surface monolayer, bearing in mind recent advances in tuning monolayer structures and using them as efficient drug delivery systems. Therapeutic self-assembled monolayers (TSAMs) were prepared by chemically attaching HS-AB to gold surfaces. Their properties were studied by voltammetry and atomic force microscopy (AFM). A gold electrode with immobilized thioglycolic acid (HS-GA) was used for comparison. The surface concentration of HS-AB on the gold surface was 0.572 nmol/cm2, determined from the area of the voltammetric reduction peaks (desorption process). The area per one molecule estimated from the voltammetry experiments was 0.291 nmol/cm2. The capacity of thus prepared electrode was also tested. The calculated capacity for the HS-AB modified electrode is 2.90 μF/cm2. The obtained value indicates that the monolayer on the gold electrode is quite well ordered and well-packed. AFM images show the formation of gold nanoparticles as a result of immersing the HS-AB modified gold electrode in an aqueous solution containing 1 mM HAuCl4·3H2O. These structures arise as a result of the interaction between the HS-AB compound adsorbed on the electrode and the AuCl4− ions. The voltammetric experiments also confirm the formation of gold structures with specific catalytic properties in the process of oxygen reduction.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorStolarczyk, Elżbieta
dc.contributor.authorKubiszewski, Marek
dc.contributor.authorSidoryk, Katarzyna
dc.contributor.authorCybulski, Marcin
dc.contributor.authorStolarczyk, Krzysztof
dc.date.accessioned2024-01-24T21:35:44Z
dc.date.available2024-01-24T21:35:44Z
dc.date.copyright2018-12-07
dc.date.issued2018
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number12
dc.description.versionFINAL_PUBLISHED
dc.description.volume8
dc.identifier.doi10.3390/NANO8121018
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/104610
dc.identifier.weblinkhttps://www.mdpi.com/2079-4991/8/12/1018/htm
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofNanomaterials
dc.relation.pagesart.no.1018
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enself-assembled monolayer
dc.subject.enthiolated abiraterone
dc.subject.enthioglycolic acid (GA)
dc.subject.enelectrochemistry
dc.subject.engold electrode
dc.subject.encapacity
dc.subject.enoxygen reduction
dc.titleDesign of therapeutic self-assembled monolayers of thiolated abiraterone
dc.typeJournalArticle
dspace.entity.typePublication