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Assessment of HMGB-1 concentration in tick-borne encephalitis and neuroborreliosis

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cris.lastimport.scopus2024-02-12T19:43:41Z
dc.abstract.enBackground The aim of this study was to determine the concentration of HMGB-1 (high mobility group box 1) in the serum and cerebrospinal fluid (CSF) of patients suffering from tick-borne encephalitis (TBE) and neuroborreliosis (NB). Focus was placed on HMGB-1 measurement in the CSF or serum in order to establish whether this could help to differentiate between NB and TBE. Methods Eighty patients with meningitis and meningoencephalitis were enrolled in the study. The patients were divided into two groups: group I comprised patients with NB (n = 40) and group II comprised patients with TBE (n = 40). The diagnosis was made based on the clinical picture, CSF examination, and the presence of specific antibodies in the serum and CSF. The control group for the evaluation of the parameters in serum were healthy blood donors (n = 25), while the control group for the evaluation of parameters in the CSF were patients in whom a central nervous system (CNS) inflammatory process was excluded. The concentrations of HMGB-1 were measured by ELISA method using a commercial kit (HMGB-1 ELISA Kit; EIAab, China). The results were analyzed using Statistica 10, Gretl, receiver operating characteristics curve (ROC), and the Pearson correlation coefficient. Results and conclusions HMGB-1 is associated with the development of inflammatory processes in the CNS caused by both tick-borne pathogens: viral (TBE) and bacterial (Lyme borreliosis). Measurement of the serum HMGB-1 concentration in the early stages of both diseases of the CNS may contribute to the differentiation between TBE and NB, which may have a clinical impact for patients bitten by ticks.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorZajkowska, Olga
dc.contributor.authorZajkowska, Joanna
dc.contributor.authorDunaj, Justyna
dc.contributor.authorŚwierzbińska, Renata
dc.contributor.authorPancewicz, Sławomir
dc.contributor.authorCzupryna, Piotr
dc.contributor.authorPenza, Paweł
dc.contributor.authorMoniuszko-Malinowska, Anna
dc.date.accessioned2024-01-24T16:57:05Z
dc.date.available2024-01-24T16:57:05Z
dc.date.copyright2018-03-17
dc.date.issued2018
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.versionFINAL_PUBLISHED
dc.description.volume70
dc.identifier.doi10.1016/J.IJID.2018.03.013
dc.identifier.issn1201-9712
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/101211
dc.identifier.weblinkhttps://www.clinicalkey.com/service/content/pdf/watermarked/1-s2.0-S1201971218300729.pdf?locale=en_US
dc.languageeng
dc.pbn.affiliationeconomics and finance
dc.relation.ispartofInternational Journal of Infectious Diseases
dc.relation.pages131-136
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.subject.enAdult
dc.subject.enAged
dc.subject.enEncephalitis
dc.subject.entick-borne - blood
dc.subject.entick-borne - cerebrospinal fluid
dc.subject.entick-borne - diagnosis
dc.subject.enEnzyme-linked immunosorbent assay
dc.subject.enFemale
dc.subject.enHMGB1 protein - blood
dc.subject.enHMGB1 protein - cerebrospinal fluid
dc.subject.enHumans
dc.subject.enLyme neuroborreliosis - blood
dc.subject.enLyme neuroborreliosis - cerebrospinal fluid
dc.subject.enLyme neuroborreliosis - diagnosis
dc.subject.enMale
dc.subject.enMiddle aged
dc.subject.enYoung adult
dc.titleAssessment of HMGB-1 concentration in tick-borne encephalitis and neuroborreliosis
dc.typeJournalArticle
dspace.entity.typePublication