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Peptide nucleic acid conjugates and their antimicrobial applications—a mini-review

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cris.lastimport.scopus2024-02-12T19:40:32Z
dc.abstract.enPeptide nucleic acid (PNA) is a nucleic acid mimic with high specificity and binding affinity to natural DNA or RNA, as well as resistance to enzymatic degradation. PNA sequences can be designed to selectively silence gene expression, which makes PNA a promising tool for antimicrobial applications. However, the poor membrane permeability of PNA remains the main limiting factor for its applications in cells. To overcome this obstacle, PNA conjugates with different molecules have been developed. This mini-review focuses on covalently linked conjugates of PNA with cell-penetrating peptides, aminosugars, aminoglycoside antibiotics, and non-peptidic molecules that were tested, primarily as PNA carriers, in antibacterial and antiviral applications. The chemistries of the conjugation and the applied linkers are also discussed.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorTrylska, Joanna
dc.contributor.authorSiekierska, Izabela
dc.contributor.authorTsylents, Uladzislava
dc.date.accessioned2024-01-25T16:22:52Z
dc.date.available2024-01-25T16:22:52Z
dc.date.issued2023
dc.description.financePublikacja bezkosztowa
dc.identifier.doi10.1007/S00249-023-01673-W
dc.identifier.issn0175-7571
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/115670
dc.identifier.weblinkhttps://link.springer.com/content/pdf/10.1007/s00249-023-01673-w.pdf
dc.languageeng
dc.pbn.affiliationphysical sciences
dc.relation.ispartofEuropean Biophysics Journal
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titlePeptide nucleic acid conjugates and their antimicrobial applications—a mini-review
dc.typeJournalArticle
dspace.entity.typePublication