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Gold Nanoparticle-Modified Poly(vinyl chloride) Surface with Improved Antimicrobial Properties for Medical Devices

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cris.lastimport.scopus2024-02-12T20:54:54Z
dc.abstract.enDespite the significant technological progress achieved in the past decades in the medical field, device-related infections carry a heavy social and economic burden. Surface modification of medical equipment is one of the most interesting approaches employed to improve the antibacterial activity of a material. Herein, we developed a process for the gold nanoparticle modification of a poly(vinyl chloride) laryngeal tube, which typically serves as an airway management device. In our study, we focused specifically on increasing the antimicrobial properties of the material while maintaining its biocompatibility. We applied two different modification methods to the poly(vinyl chloride) laryngeal tube. An increase in the antimicrobial activity of the surface was observed for both methods. In addition, the adsorption of bacterial cells on the material surface was assessed. We determined that the number of colonies cultured in the presence of the gold nanoparticle-modified samples or absorbed to the material surface decreased significantly compared with the control group. The trend was observed for both Gram-positive and Gram-negative strains. Moreover, it was established that the designed material did not exhibit a lethal impact on a control cell line. Finally, we noted discrepancies in the growth of bacteria cultured in the presence of modified or unmodified PVC material as well as differences in cell adherence to its surface. The proposed poly(vinyl chloride) modifications are most effective against Gram-positive bacteria, especially L. monocytogenes. Nevertheless, it ought to be emphasized that due to their different properties, each strain requires an individual approach.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGranicka, Ludomira
dc.contributor.authorKwiatkowska, Angelika
dc.contributor.authorGRZECZKOWICZ, Anna
dc.contributor.authorSobczak, Kamil
dc.contributor.authorDarowski, Marek
dc.contributor.authorStachowiak, Radosław
dc.contributor.authorBącal, Paweł
dc.contributor.authorBielecki, Jacek
dc.contributor.authorKozarski, Maciej
dc.date.accessioned2024-01-25T02:21:56Z
dc.date.available2024-01-25T02:21:56Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.identifier.doi10.1166/JBN.2018.2530
dc.identifier.issn1550-7033
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108041
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofJournal of Biomedical Nanotechnology
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enANTIBACTERIAL PROPERTIES
dc.subject.enGOLD NANOPARTICLES
dc.subject.enLARYNGEAL TUBE
dc.subject.enPOLYVINYL CHLORIDE
dc.titleGold Nanoparticle-Modified Poly(vinyl chloride) Surface with Improved Antimicrobial Properties for Medical Devices
dc.typeJournalArticle
dspace.entity.typePublication