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Heat shock proteins create a signature to predict the clinical outcome in breast cancer.

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dc.abstract.enUtilizing The Cancer Genome Atlas (TCGA) and KM plotter databases we identified six heat shock proteins associated with survival of breast cancer patients. The survival curves of samples with high and low expression of heat shock genes were compared by log-rank test (Mantel-Haenszel). Interestingly, patients overexpressing two identified HSPs - HSPA2 and DNAJC20 exhibited longer survival, whereas overexpression of other four HSPs - HSP90AA1, CCT1, CCT2, CCT6A resulted in unfavorable prognosis for breast cancer patients. We explored correlations between expression level of HSPs and clinicopathological features including tumor grade, tumor size, number of lymph nodes involved and hormone receptor status. Additionally, we identified a novel signature with the potential to serve as a prognostic model for breast cancer. Using univariate Cox regression analysis followed by multivariate Cox regression analysis, we built a risk score formula comprising prognostic HSPs (HSPA2, DNAJC20, HSP90AA1, CCT1, CCT2) and tumor stage to identify high-risk and low-risk cases. Finally, we analyzed the association of six prognostic HSP expression with survival of patients suffering from other types of cancer than breast cancer. We revealed that depending on cancer type, each of the six analyzed HSPs can act both as a positive, as well as a negative regulator of cancer development. Our study demonstrates a novel HSP signature for the outcome prediction of breast cancer patients and provides a new insight into ambiguous role of these proteins in cancer development.
dc.abstract.plNa bazie danych z TCGA zbudowano model predykcyjny, który przewiduje ryzyko śmierci spowodowanej przez nowotwór
dc.affiliationUniwersytet Warszawski
dc.contributor.authorŻylicz, Alicja
dc.contributor.authorBiecek, Przemysław
dc.contributor.authorKlimczak, Marta
dc.contributor.authorŻylicz, Maciej
dc.date.accessioned2024-01-25T03:00:00Z
dc.date.available2024-01-25T03:00:00Z
dc.date.copyright2019-05-17
dc.date.issued2019
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number1
dc.description.versionFINAL_PUBLISHED
dc.description.volume9
dc.identifier.doi10.1038/S41598-019-43556-1
dc.identifier.issn2045-2322
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108330
dc.identifier.weblinkhttps://www.nature.com/articles/s41598-019-43556-1
dc.languageeng
dc.pbn.affiliationcomputer and information sciences
dc.relation.ispartofScientific Reports
dc.relation.pages7507:1-15
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enHeat shock proteins, TCGA, cancer
dc.subject.plbiałka szoku termicznego, TCGA, nowortowy
dc.titleHeat shock proteins create a signature to predict the clinical outcome in breast cancer.
dc.typeJournalArticle
dspace.entity.typePublication