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Decomposition of Flavonols in the Presence of Saliva

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dc.abstract.enIn this study, the LC-MS/MS was applied to explore the stability of four common dietary flavonols, kaempferol, quercetin, isorhamnetin, and myricetin, in the presence of hydrogen peroxide and saliva. In addition, the influence of saliva on the representative quercetin glycosides, rutin, quercitrin, hyperoside, and spiraeoside was examined. Our study showed that, regardless of the oxidative agent used, flavonols stability decreases with increasing B-ring substitution. The decomposition of analyzed compounds was based on their splitting by the opening the heterocyclic C-ring and realizing more simple aromatic compounds. The dead-end products corresponded to dierent benzoic acid derivatives derived from B-ring. Kaempferol, quercetin, isorhamnetin, and myricetin were transformed into 4-hydroxybeznoic acid, protocatechuic acid, vanillic acid, and gallic acid, respectively. Additionally, for quercetin and myricetin, two intermediate depsides and 2,4,6-trihydroxybenzoic acid derived from A-ring were detected. All analyzed glycosides were resistant to hydrolysis in the presence of saliva. Based on our data, saliva was proven to be a next oxidative agent which leads to the formation of corresponding phenolic acids. Hence, studies on flavonols’ metabolism should take into consideration that the flavonols decomposition starts in the oral cavity; hence, in subsequent parts of the human digestive tract, they could be present not in their parent form but as phenolic acids. Further analyses of the influence of saliva on flavonols glycosides need to be performed due to the possible interindividual fluctuations.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBiesaga, Magdalena
dc.contributor.authorRogozinska, Malgorzata
dc.date.accessioned2024-01-24T21:18:17Z
dc.date.available2024-01-24T21:18:17Z
dc.date.copyright2020-10-26
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number21
dc.description.versionFINAL_PUBLISHED
dc.description.volume10
dc.identifier.doi10.3390/APP10217511
dc.identifier.issn1454-5101
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/104407
dc.identifier.weblinkhttps://www.mdpi.com/2076-3417/10/21/7511/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofApplied Sciences
dc.relation.pages7511
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enflavonols
dc.subject.enH2O2
dc.subject.ensaliva
dc.subject.enmetabolism
dc.subject.enoxidation
dc.subject.enLC-MS/MS
dc.titleDecomposition of Flavonols in the Presence of Saliva
dc.typeJournalArticle
dspace.entity.typePublication