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The Response of Pseudomonas aeruginosa PAO1 to UV-activated Titanium Dioxide/Silica Nanotubes

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cris.lastimport.scopus2024-02-12T20:54:17Z
dc.abstract.enPseudomonas aeruginosa is a bacterium of high clinical and biotechnological importance thanks to its high adaptability to environmental conditions. The increasing incidence of antibiotic-resistant strains has created a need for alternative methods to increase the chance of recovery in infected patients. Various nanomaterials have the potential to be used for this purpose. Therefore, we aimed to study the physiological response of P. aeruginosa PAO1 to titanium dioxide/silica nanotubes. The results suggest that UV light-irradiated nanomaterial triggers strong agglomeration in the studied bacteria that was confirmed by microscopy, spectrophotometry, and flow cytometry. The effect was diminished when the nanomaterial was applied without initial irradiation, with UV light indicating that the creation of reactive oxygen species could play a role in this phenomenon. The nanocomposite also affected biofilm formation ability. Even though the biomass of biofilms was comparable, the viability of cells in biofilms was upregulated in 48-hour biofilms. Furthermore, from six selected genes, the mexA coding efflux pump was upregulated, which could be associated with an interaction with TiO2. The results show that titanium dioxide/silica nanotubes may alter the physiological and metabolic functions of P. aeruginosa PAO1.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorAugustyniak, Adrian
dc.contributor.authorGrygorcewicz, Bartłomiej
dc.contributor.authorCendrowski, Krzysztof
dc.contributor.authorAugustyniak, Adrian
dc.contributor.authorMijowska, Ewa
dc.contributor.authorTrukawka, Martyna
dc.contributor.authorNawrotek, Paweł
dc.contributor.authorPopowska, Magdalena
dc.contributor.authorNawrotek, Paweł
dc.contributor.authorJabłońska, Joanna
dc.contributor.authorGrygorcewicz, Bartłomiej
dc.contributor.authorJabłońska, Joanna
dc.date.accessioned2024-01-26T10:37:19Z
dc.date.available2024-01-26T10:37:19Z
dc.date.issued2020
dc.description.financePublikacja bezkosztowa
dc.identifier.doi10.3390/IJMS21207748
dc.identifier.issn1422-0067
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/122980
dc.identifier.weblinkhttps://www.mdpi.com/1422-0067/21/20/7748
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.pages1-15, [nr art.] 7748
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enbacterial physiology
dc.subject.encells agglomeration
dc.subject.enstimulation
dc.subject.ensilica nanocomposite
dc.titleThe Response of Pseudomonas aeruginosa PAO1 to UV-activated Titanium Dioxide/Silica Nanotubes
dc.typeJournalArticle
dspace.entity.typePublication