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Enhancement of Phytosterol and Triterpenoid Production in Plant Hairy Root Cultures—Simultaneous Stimulation or Competition?

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dc.abstract.enPlant in vitro cultures, including hairy roots, can be applied for controlled production of valuable natural products, such as triterpenoids and sterols. These compounds originate from the common precursor squalene. Sterols and triterpenoids distinctly differ in their functions, and the 2,3-oxidosqualene cyclization step is often regarded as a branch point between primary and secondary (more aptly: general and specialized) metabolism. Considering the crucial role of phytosterols as membrane constituents, it has been postulated that unconstrained biosynthesis of triterpenoids can occur when sterol formation is already satisfied, and these compounds are no longer needed for cell growth and division. This hypothesis seems to follow directly the growth-defense trade-off plant dilemma. In this review, we present some examples illustrating the specific interplay between the two divergent pathways for sterol and triterpenoid biosynthesis appearing in root cultures. These studies were significant for revealing the steps of the biosynthetic pathway, understanding the role of particular enzymes, and discovering the possibility of gene regulation. Currently, hairy roots of many plant species can be considered not only as an efficient tool for production of phytochemicals, but also as suitable experimental models for investigations on regulatory mechanisms of plant metabolism.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorRogowska, Agata
dc.contributor.authorSzakiel, Anna
dc.date.accessioned2024-01-24T22:48:33Z
dc.date.available2024-01-24T22:48:33Z
dc.date.copyright2021-09-27
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number10
dc.description.versionFINAL_PUBLISHED
dc.description.volume10
dc.identifier.doi10.3390/PLANTS10102028
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/106233
dc.identifier.weblinkhttps://www.mdpi.com/2223-7747/10/10/2028/pdf
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofPlants
dc.relation.pages2028
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleEnhancement of Phytosterol and Triterpenoid Production in Plant Hairy Root Cultures—Simultaneous Stimulation or Competition?
dc.typeJournalArticle
dspace.entity.typePublication