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Complexing daunorubicin with beta-cyclodextrin derivative increases drug intercalation into DNA

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cris.lastimport.scopus2024-02-12T19:03:59Z
dc.abstract.enA non-toxic lipoic acid derivative of β-cyclodextrin (βCDLip) with an electron-rich aromatic linker was studied as a carrier for the drug daunorubicin with the aim of increasing the intercalation efficiency of the drug into the double stranded DNA. The impact of cyclodextrins modified with lipoic acid on the interaction of daunorubicin with dsDNA was investigated by UV–vis spectroscopy and square wave voltammetry, and described using the McGhee and von Hippel model. The changes of the stability constants of the complexes reveal the dependence of drug binding efficiency on pH and explain the observed changes in the extent of drug intercalation into dsDNA.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBilewicz, Renata
dc.contributor.authorKrzak, Agata
dc.contributor.authorMajdecki, Maciej
dc.contributor.authorŚwięch, Olga
dc.date.accessioned2024-01-24T19:52:05Z
dc.date.available2024-01-24T19:52:05Z
dc.date.issued2017
dc.description.financeNie dotyczy
dc.description.volume247
dc.identifier.doi10.1016/J.ELECTACTA.2017.06.140
dc.identifier.issn0013-4686
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/103438
dc.identifier.weblinkhttps://doi.org/10.1016/j.electacta.2017.06.140
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofElectrochimica Acta
dc.relation.pages139-148
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enDaunorubicin
dc.subject.enCyclodextrin
dc.subject.endsDNA
dc.subject.enntercalation complex
dc.subject.enMcGhee-von Hippel method
dc.titleComplexing daunorubicin with beta-cyclodextrin derivative increases drug intercalation into DNA
dc.typeJournalArticle
dspace.entity.typePublication