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Analysis of global dynamics for HIV-infection of CD4+T cells and its treatment

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cris.lastimport.scopus2024-02-12T19:01:11Z
dc.abstract.enAntiviral therapy for HIV-infected patients has greatly improved in recent years. Administration of drug combinations consisting of two or more different drugs can reduce and maintain virus load below detection level in many patients. Cyclic administration of the immune activator interleukin-2 (IL-2) in combination with highly active antiretroviral therapy (HAART) has been suggested as an effective strategy to realize long-term control of HIV replication in vivo. In this article, we formulate a mathematical model of the immune response for HIV-infected individual in the presence of HAART and IL-2. We look for the conditions under which the immune system recovers by applying IL-2 as an immune activator along with HAART. From the analytical point of view this means global stability of the disease-free equilibrium. Comprehensive numerical simulations are presented to illustrate the analytical results.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBodzioch, Mariusz
dc.contributor.authorChoiński, Marcin
dc.contributor.authorForyś, Urszula
dc.date.accessioned2024-01-24T16:29:26Z
dc.date.available2024-01-24T16:29:26Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number1
dc.description.volume46
dc.identifier.doi10.14708/MA.V46I1.6369
dc.identifier.issn1730-2668
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/100617
dc.identifier.weblinkhttp://yadda.icm.edu.pl/yadda/element/bwmeta1.element.ojs-doi-10_14708_ma_v46i1_6369
dc.languageeng
dc.pbn.affiliationmathemathics
dc.relation.ispartofMathematica Applicanda
dc.relation.pages35-48
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enHIV
dc.subject.enCD4+T cell, IL-2
dc.subject.enHAART therapy
dc.subject.englobal stability
dc.titleAnalysis of global dynamics for HIV-infection of CD4+T cells and its treatment
dc.typeJournalArticle
dspace.entity.typePublication