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Dostęp zamkniętyTricarbonylrhenium(I) complexes with the N-methylpyridine-2-carbothioamide ligand – Synthesis, characterization and cytotoxicity studies
| cris.lastimport.scopus | 2024-02-12T19:01:12Z |
| dc.abstract.en | A new series of tricarbonyl complexes of rhenium(I) in the ‘2 + 1’ system with the bidentate ligand N-methylpyridine-2-carbothioamide (NC5H4-CS-NH-CH3, LH(Me)NS) and a monodentate ligand, being either an anion (Cl, Br, I or SCN) or a neutral molecule (3,5-dimethylpyrazole (Hdmpz) or imidazole (Him)), was synthesized. The use of mixed ligands leads to the formation of neutral or cationic (in the form of PF6− salts) tricarbonylrhenium(I) complexes: [Re(CO)3(LH(Me)NS)X] (X = Cl, Br, I, NCS) (complexes 1–4) and [Re(CO)3(LH(Me)NS)Y]+ (Y = Hdmpz, Him) (5 and 6), respectively. In case of the [Re(CO)3(LH(Me)NS)NCS] complex two polymorphic forms (4a and 4b) have been distinguished. Crystal structure of all complexes was determined by single-crystal X-ray diffraction method and the results were compared with the molecular structures obtained from DFT calculations. The compounds were characterized by FT-IR, NMR, UV-Vis and HPLC techniques. IR and UV-Vis spectra were also simulated by DFT and TD-DFT methods. Cytotoxicity of the complexes was estimated using human ovarian cancer cell line (A2780), its cisplatin resistant cell line (A2780cis) and non-cancerous human embryonic kidney cells (Hek-293). The toxicity of newly synthesized complexes was comparable to cisplatin when tested against both cancerous cell lines (IC50 = 2–49 μM), but lower than cisplatin towards non-cancerous cells (IC50 = 6–63 μM). Among them, the complexes with chloride and iodide anions exhibit remarkable cytotoxicities. |
| dc.affiliation | Uniwersytet Warszawski |
| dc.contributor.author | Męczyńska-Wielgosz, Sylwia |
| dc.contributor.author | Mieczkowski, Józef |
| dc.contributor.author | Łyczko, Krzysztof |
| dc.contributor.author | Łyczko, Monika |
| dc.contributor.author | Kruszewski, Marcin |
| dc.date.accessioned | 2024-01-26T11:06:46Z |
| dc.date.available | 2024-01-26T11:06:46Z |
| dc.date.issued | 2018 |
| dc.description.finance | Nie dotyczy |
| dc.description.volume | 866 |
| dc.identifier.doi | 10.1016/J.JORGANCHEM.2018.04.008 |
| dc.identifier.issn | 0022-328X |
| dc.identifier.uri | https://repozytorium.uw.edu.pl//handle/item/123802 |
| dc.identifier.weblink | https://www.sciencedirect.com/science/article/pii/S0022328X18302389 |
| dc.language | eng |
| dc.pbn.affiliation | chemical sciences |
| dc.relation.ispartof | Journal of Organometallic Chemistry |
| dc.relation.pages | 59-71 |
| dc.rights | ClosedAccess |
| dc.sciencecloud | nosend |
| dc.subject.en | Tricarbonylrhenium(I) complexes |
| dc.subject.en | N-methylpyridine-2-carbothioamide |
| dc.subject.en | Crystal structure |
| dc.subject.en | DFT calculations |
| dc.subject.en | Cytotoxicity |
| dc.subject.en | IC50 |
| dc.title | Tricarbonylrhenium(I) complexes with the N-methylpyridine-2-carbothioamide ligand – Synthesis, characterization and cytotoxicity studies |
| dc.type | JournalArticle |
| dspace.entity.type | Publication |