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High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones

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dc.abstract.enThe application of high pressure (up to 9 kbar) allows for relatively fast (1–5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2–1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (<10%) of products were formed after 20 h.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKasztelan, Adrian
dc.contributor.authorKopyt, Michał
dc.contributor.authorKwiatkowski, Piotr
dc.contributor.authorAdamczyk, Kamil
dc.contributor.authorCholewiak, Agnieszka
dc.date.accessioned2024-01-25T03:28:17Z
dc.date.available2024-01-25T03:28:17Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number23
dc.description.volume16
dc.identifier.doi10.1039/C8OB00561C
dc.identifier.issn1477-0520
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108509
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofOrganic and Biomolecular Chemistry
dc.relation.pages4365-4371
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleHigh pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones
dc.typeJournalArticle
dspace.entity.typePublication