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Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

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cris.lastimport.scopus2024-02-12T19:01:52Z
dc.abstract.enSuperparamagnetic iron oxide-based nanoparticles (SPIONs) are promising carriers as targeted drug delivery vehicles, because they can be guided to their target with the help of an external magnetic field. Functionalization of nanoparticles' surface with molecules, which bind with high affinity to receptors on target tissue significantly facilitates delivery of coated nanoparticles to their targeted site. Here, we demonstrate conjugation of an antiangiogenic and antitumor peptide ATWLPPR (A7R) to SPIONs modified with sebacic acid (SPIONs-SA). Successful conjugation was confirmed by various analytical techniques (FTIR, SERS, SEM-EDS, TEM, TGA). Cell cytotoxicity studies, against two cell lines (HUVEC and MDA-MB231) indicated that SPIONs modified with A7R reduced HUVEC cell viability at concentrations higher than 0.01 mg Fe/mL, in comparison to cells that were exposed to either the nanoparticles modified with sebacic acid or A7R peptide solely, what might be partially caused by a process of internalization.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorMisicka-Kęsik, Aleksandra
dc.contributor.authorPuszko, Anna
dc.contributor.authorNieścioruk, Anna
dc.contributor.authorKrólikowska, Agata
dc.contributor.authorPerret, Gerard Y.
dc.contributor.authorNieciecka, Dorota
dc.contributor.authorKosson, Piotr
dc.contributor.authorKrysiński, Paweł
dc.date.accessioned2024-01-25T16:37:31Z
dc.date.available2024-01-25T16:37:31Z
dc.date.copyright2017-04-26
dc.date.issued2017
dc.description.accesstimeBEFORE_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number5
dc.description.versionFINAL_PUBLISHED
dc.description.volume19
dc.identifier.doi10.1007/S11051-017-3859-X
dc.identifier.issn1388-0764
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/115889
dc.identifier.weblinkhttps://link.springer.com/article/10.1007%2Fs11051-017-3859-x
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofJournal of Nanoparticle Research
dc.relation.pages160
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enSuperparamagnetic nanoparticles
dc.subject.enSPIONs
dc.subject.enAngiogenesis
dc.subject.enA7R peptide
dc.subject.enNeuropilin-1
dc.subject.enHealth effects
dc.titlePhysicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R
dc.typeJournalArticle
dspace.entity.typePublication