Artykuł w czasopiśmie
Brak miniatury
Licencja
 

The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans.

Uproszczony widok
cris.lastimport.scopus2024-02-12T20:55:14Z
dc.abstract.enIn Aspergillus nidulans, nitrogen and carbon metabolism are under the control of wide-domain regulatory systems, including nitrogen metabolite repression, carbon catabolite repression and the nutrient starvation response. Transcriptomic analysis of the wild type strain grown under different combinations of carbon and nitrogen regimes was performed, to identify differentially regulated genes. Carbon metabolism predominates as the most important regulatory signal but for many genes, both carbon and nitrogen metabolisms coordinate regulation. To identify mechanisms coordinating nitrogen and carbon metabolism, we tested the role of AreB, previously identified as a regulator of genes involved in nitrogen metabolism. Deletion of areB has significant phenotypic effects on the utilization of specific carbon sources, confirming its role in the regulation of carbon metabolism. AreB was shown to regulate the expression of areA, tamA, creA, xprG and cpcA regulatory genes suggesting areB has a range of indirect, regulatory effects. Different isoforms of AreB are produced as a result of differential splicing and use of two promoters which are differentially regulated by carbon and nitrogen conditions. These isoforms are likely to be functionally distinct and thus contributing to the modulation of AreB activity.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorWęgleński, Piotr
dc.contributor.authorMacios, Maria
dc.contributor.authorDzikowska, Agnieszka
dc.contributor.authorCaddick, Mark X.
dc.contributor.authorWeedall, Gareth D.
dc.contributor.authorKoper, Michał
dc.contributor.authorOrmaniec, Patrycja Chudzicka -
dc.date.accessioned2024-01-26T10:47:04Z
dc.date.available2024-01-26T10:47:04Z
dc.date.copyright2019-04-02
dc.date.issued2019
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.numberfnz066
dc.description.versionFINAL_PUBLISHED
dc.description.volume366
dc.identifier.doi10.1093/FEMSLE/FNZ066
dc.identifier.issn0378-1097
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/123078
dc.identifier.weblinkhttps://academic.oup.com/femsle/article/366/6/fnz066/5426211
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofFEMS Microbiology Letters
dc.relation.pages1-11
dc.rightsOther
dc.sciencecloudnosend
dc.titleThe role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans.
dc.typeJournalArticle
dspace.entity.typePublication