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Sequencing and Analysis of the Complete Organellar Genomes of Prototheca wickerhamii

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cris.lastimport.scopus2024-02-12T19:33:56Z
dc.abstract.enOf the Prototheca genus, Prototheca wickerhamii has the highest clinical significance in humans. However, neither nuclear nor organellar genomes of this species were sequenced until now. The hitherto determined and analyzed mitochondrial and plastid genomes of the alleged P. wickerhamii species belong in fact to another species, recently named Prototheca xanthoriae. This study provides a first insight into the organellar genomes of a true P. wickerhamii (type strain ATCC 16529). The P. wickerhamii mitochondrion had a 53.8-kb genome, which was considerably larger than that of Prototheca ciferrii (formerly Prototheca zopfii gen. 1) and Prototheca bovis (formerly Prototheca zopfii gen. 2), yet similarly functional, with the differences in size attributable to a higher number of introns and the presence of extra unique putative genes. The 48-kb plastid genome of P. wickerhamii, compared to autotrophic Trebouxiophyceae, was highly reduced due to the elimination of the photosynthesis-related genes. The gene content of the plastid genome of P. wickerhamii was, however, very similar to other colorless Prototheca species. Plastid genome-based phylogeny reinforced the polyphyly of the genus Prototheca, with Helicosporidium and Auxenochlorella branching within clades of Prototheca species. Phylogenetic reconstruction also confirmed the close relationship of P. wickerhamii and P. xanthoriae, which is reflected in the synteny of their organellar genomes. Interestingly, the entire set of atp genes was lost in P. wickerhamii plastid genome while being preserved in P. xanthoriae.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGawor, Jan
dc.contributor.authorGromadka, Robert
dc.contributor.authorSiedlecki, Paweł
dc.contributor.authorMaciszewski, Kacper
dc.contributor.authorPomorski, Jan J.
dc.contributor.authorGromadka, Agnieszka
dc.contributor.authorBakuła, Zofia
dc.contributor.authorJagielski, Tomasz
dc.contributor.authorKarnkowska, Anna
dc.date.accessioned2024-01-26T07:34:09Z
dc.date.available2024-01-26T07:34:09Z
dc.date.copyright2020-09-01
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financeŚrodki finansowe przyznane na realizację projektu w zakresie badań naukowych lub prac rozwojowych
dc.description.numberbrak
dc.description.versionFINAL_PUBLISHED
dc.description.volume11
dc.identifier.doi10.3389/FPLS.2020.01296
dc.identifier.issn1664-462X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/119650
dc.identifier.weblinkhttps://www.frontiersin.org/article/10.3389/fpls.2020.01296/full
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofFrontiers in Plant Science
dc.relation.pages1296
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enPrototheca wickerhamii
dc.subject.enprotothecosis
dc.subject.encolorless algae
dc.subject.enmitochondrial genome
dc.subject.enplastid genome
dc.titleSequencing and Analysis of the Complete Organellar Genomes of Prototheca wickerhamii
dc.typeJournalArticle
dspace.entity.typePublication