Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BYCC-BY - Uznanie autorstwa
 

Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind

Uproszczony widok
cris.lastimport.scopus2024-02-12T19:35:47Z
dc.abstract.enCanonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor 1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan development and tissue renewal. Although much evidence has associated canonical Wnt/β‐catenin signaling with mood disorders, the mechanistic links are still unknown. Many components of the canonical Wnt pathway are involved in cellular processes that are unrelated to classical canonical Wnt signaling, thus further blurring the picture. The present review critically evaluates the involvement of classical Wnt/β‐catenin signaling in developmental processes that putatively underlie the pathology of mental illnesses. Particular attention is given to the roles of LEF1/TCFs, which have been discussed surprisingly rarely in this context. Highlighting recent discoveries, we propose that alterations in the activity of LEF1/TCFs, and particularly of transcription factor 7‐like 2 (TCF7L2), result in defects previously associated with neuropsychiatric disorders, including imbalances in neurogenesis and oligodendrogenesis, the functional disruption of thalamocortical circuitry and dysfunction of the habenula.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBrożko, Nikola
dc.contributor.authorBem, Joanna
dc.contributor.authorSzewczyk, Łukasz
dc.contributor.authorWiśniewska, Marta
dc.contributor.authorNagalski, Andrzej
dc.contributor.authorKoziński, Kamil
dc.contributor.authorLipiec, Marcin
dc.contributor.authorChakraborty, Chaitali
dc.date.accessioned2024-01-23T07:21:54Z
dc.date.available2024-01-23T07:21:54Z
dc.date.copyright2019-06-20
dc.date.issued2019
dc.description.accesstimeBEFORE_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number13
dc.description.versionFINAL_PUBLISHED
dc.description.volume593
dc.identifier.doi10.1002/1873-3468.13502
dc.identifier.issn0014-5793
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/125166
dc.identifier.weblinkhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F1873-3468.13502
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofFEBS Letters
dc.relation.pages1654-1674
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleWnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind
dc.typeJournalArticle
dspace.entity.typePublication