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Mitochondrial stress-dependent regulation of cellular protein synthesis.

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cris.lastimport.scopus2024-02-12T19:32:56Z
dc.abstract.enThe production of newly synthesized proteins is vital for all cellular functions and is a determinant of cell growth and proliferation. The synthesis of polypeptide chains from mRNA molecules requires sophisticated machineries and mechanisms that need to be tightly regulated, and adjustable to current needs of the cell. Failures in the regulation of translation contribute to the loss of protein homeostasis, which can have deleterious effects on cellular function and organismal health. Unsurprisingly, the regulation of translation appears to be a crucial element in stress response mechanisms. This review provides an overview of mechanisms that modulate cytosolic protein synthesis upon cellular stress, with a focus on the attenuation of translation in response to mitochondrial stress. We then highlight links between mitochondrion-derived reactive oxygen species and the attenuation of reversible cytosolic translation through the oxidation of ribosomal proteins at their cysteine residues. We also discuss emerging concepts of how cellular mechanisms to stress are adapted, including the existence of alternative ribosomes and stress granules, and the regulation of co-translational import upon organelle stress.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorUszczyńska-Ratajczak, Barbara
dc.contributor.authorTopf, Ulrike
dc.contributor.authorChacińska, Agnieszka
dc.date.accessioned2024-01-25T12:40:52Z
dc.date.available2024-01-25T12:40:52Z
dc.date.copyright2019-04-26
dc.date.issued2019
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number8
dc.description.versionFINAL_PUBLISHED
dc.description.volume132
dc.identifier.doi10.1242/JCS.226258
dc.identifier.issn0021-9533
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/112684
dc.identifier.weblinkhttp://jcs.biologists.org/content/132/8/jcs226258.abstract
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofJournal of Cell Science
dc.relation.pages226258
dc.rightsOther
dc.sciencecloudnosend
dc.subject.enCytosolic translation
dc.subject.enMitochondrial stress
dc.subject.enReactive oxygen species
dc.subject.enRedox switches
dc.titleMitochondrial stress-dependent regulation of cellular protein synthesis.
dc.typeJournalArticle
dspace.entity.typePublication