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Dostęp zamkniętyOrigin of Life and the Phosphate Transfer Catalyst
| cris.lastimport.scopus | 2024-02-12T19:35:32Z |
| dc.abstract.en | In this paper, we revisit several issues relevant to origin-of-life research and propose a Phosphate Transfer Catalyst hypothesis that furthers our understanding of some of the key events in prebiotic chemical evolution. In the Phosphate Transfer Catalyst hypothesis, we assume the existence of hypothetical metallopeptides with phosphate transfer activity that use abundant polyphosphates as both substrates and energy sources. Nonspecific catalysis by this phosphate transfer catalyst would provide a variety of different products such as phosphoryl amino acids, nucleosides, polyphosphate nucleotides, nucleic acids, and aminoacylated nucleic acids. Moreover, being an autocatalytic set and metabolic driver at the same time, it could possibly replicate itself and produce a collective system of two polymerases; a nucleic acid able to catalyze peptide bond formation and a peptide able to polymerize nucleic acids. The genetic code starts at first as a system that reduces the energy barrier by bringing substrates (2¢/3¢ aminoacyl-nucleotides) together, an ancestral form of the catalysis performed by modern ribosomes. |
| dc.affiliation | Uniwersytet Warszawski |
| dc.contributor.author | Wieczorek, Rafał |
| dc.contributor.author | Piast, Radosław |
| dc.date.accessioned | 2024-01-25T16:09:28Z |
| dc.date.available | 2024-01-25T16:09:28Z |
| dc.date.issued | 2017 |
| dc.description.finance | Nie dotyczy |
| dc.description.number | 3 |
| dc.description.volume | 17 |
| dc.identifier.doi | 10.1089/AST.2015.1463 |
| dc.identifier.issn | 1531-1074 |
| dc.identifier.uri | https://repozytorium.uw.edu.pl//handle/item/115070 |
| dc.language | eng |
| dc.pbn.affiliation | chemical sciences |
| dc.relation.ispartof | Astrobiology |
| dc.relation.pages | 277-285 |
| dc.rights | ClosedAccess |
| dc.sciencecloud | nosend |
| dc.subject.en | Origin of life—Prebiotic chemistry—Catalysis—Nucleic acids |
| dc.title | Origin of Life and the Phosphate Transfer Catalyst |
| dc.type | JournalArticle |
| dspace.entity.type | Publication |