Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BYCC-BY - Uznanie autorstwa
 

The Role of VEGF Receptors as Molecular Target in Nuclear Medicine for Cancer Diagnosis and Combination Therapy

Uproszczony widok
cris.lastimport.scopus2024-02-12T19:50:50Z
dc.abstract.enOne approach to anticancer treatment is targeted anti-angiogenic therapy (AAT) based on prevention of blood vessel formation around the developing cancer cells. It is known that vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors (VEGFRs) play a pivotal role in angiogenesis process; hence, application of angiogenesis inhibitors can be an effective approach in anticancer combination therapeutic strategies. Currently, several types of molecules have been utilised in targeted VEGF/VEGFR anticancer therapy, including human VEGF ligands themselves and their derivatives, anti-VEGF or anti-VEGFR monoclonal antibodies, VEGF binding peptides and small molecular inhibitors of VEGFR tyrosine kinases. These molecules labelled with diagnostic or therapeutic radionuclides can become, respectively, diagnostic or therapeutic receptor radiopharmaceuticals. In targeted anti-angiogenic therapy, diagnostic radioagents play a unique role, allowing the determination of the emerging tumour, to monitor the course of treatment, to predict the treatment outcomes and, first of all, to refer patients for AAT. This review provides an overview of design, synthesis and study of radiolabelled VEGF/VEGFR targeting and imaging agents to date. Additionally, we will briefly discuss their physicochemical properties and possible application in combination targeted radionuclide tumour therapy.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorMisicka-Kęsik, Aleksandra
dc.contributor.authorMasłowska, Katarzyna
dc.contributor.authorHalik, Paweł Krzysztof
dc.contributor.authorGniazdowska, Ewa
dc.contributor.authorTymecka, Dagmara
dc.date.accessioned2024-01-26T10:47:13Z
dc.date.available2024-01-26T10:47:13Z
dc.date.copyright2021-03-03
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number5
dc.description.versionFINAL_PUBLISHED
dc.description.volume13
dc.identifier.doi10.3390/CANCERS13051072
dc.identifier.issn2072-6694
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/123091
dc.identifier.weblinkhttps://www.mdpi.com/2072-6694/13/5/1072/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofCancers
dc.relation.pages1072
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enVEGF
dc.subject.enVEGF receptors
dc.subject.enRadiopharmaceuticals
dc.subject.enAnti-angiogenic therapy
dc.titleThe Role of VEGF Receptors as Molecular Target in Nuclear Medicine for Cancer Diagnosis and Combination Therapy
dc.typeJournalArticle
dspace.entity.typePublication