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Exploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives

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dc.abstract.enNew derivatives of aminoglycosides containing 6[prime or minute]-carboxylic acid or 6[prime or minute]-amide on their ring I were designed, synthesized and their ability to readthrough nonsense mutations was examined in vitro, along with the protein translation inhibition in prokaryotic and eukaryotic systems. The observed structure-activity relationships, along with the comparative molecular dynamics simulations within the eukaryotic rRNA decoding site, showed high sensitivity of 6[prime or minute]-position to substitution, indicating that the rational design of potent stop-codon read-through inducers requires consideration of not only the structure and energetics of the drug-RNA interaction but also the dynamics associated with that interaction.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorTrylska, Joanna
dc.contributor.authorZalman, Bat-Hen
dc.contributor.authorPIEŃKO, TOMASZ
dc.contributor.authorBaasov, Timor
dc.contributor.authorSabbavarapu, Narayana Murthy
dc.date.accessioned2024-01-25T00:10:10Z
dc.date.available2024-01-25T00:10:10Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.volume3
dc.identifier.doi10.1039/C8MD00001H
dc.identifier.issn2040-2503
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/106812
dc.identifier.weblinkhttp://dx.doi.org/10.1039/C8MD00001H
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofMedChemComm
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleExploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives
dc.typeJournalArticle
dspace.entity.typePublication