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Molecular Modeling of Histamine Receptors—Recent Advances in Drug Discovery

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cris.lastimport.scopus2024-02-12T19:51:17Z
dc.abstract.enThe recent developments of fast reliable docking, virtual screening and other algorithms gave rise to discovery of many novel ligands of histamine receptors that could be used for treatment of allergic inflammatory disorders, central nervous system pathologies, pain, cancer and obesity. Furthermore, the pharmacological profiles of ligands clearly indicate that these receptors may be considered as targets not only for selective but also for multi-target drugs that could be used for treatment of complex disorders such as Alzheimer's disease. Therefore, analysis of protein-ligand recognition in the binding site of histamine receptors and also other molecular targets has become a valuable tool in drug design toolkit. This review covers the period 2014-2020 in the field of theoretical investigations of histamine receptors mostly based on molecular modeling as well as the experimental characterization of novel ligands of these receptors.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorFilipek, Sławomir
dc.contributor.authorMiszta, Przemysław
dc.contributor.authorJain, Pakhuri
dc.date.accessioned2024-01-25T12:53:25Z
dc.date.available2024-01-25T12:53:25Z
dc.date.copyright2021-03-22
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number6
dc.description.versionFINAL_PUBLISHED
dc.description.volume26
dc.identifier.doi10.3390/MOLECULES26061778
dc.identifier.issn1420-3049
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/112869
dc.identifier.weblinkhttps://www.mdpi.com/1420-3049/26/6/1778/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofMolecules
dc.relation.pages1778
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleMolecular Modeling of Histamine Receptors—Recent Advances in Drug Discovery
dc.typeJournalArticle
dspace.entity.typePublication