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Alkylation of the K-Region in a Sterically Hindered Pyrene Carboxamide via Directed Reaction with Alkyllithiums under Air

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cris.lastimport.scopus2024-02-12T19:02:58Z
dc.abstract.enSterically hindered N,2,7-tri-tert-butylpyrene-1-carboxamide treated with n-BuLi, i-BuLi, s-BuLi, and n-HexLi in THF in the presence of TMEDA and air afforded trans-N,2,7-tri-tert-butylpyrene-10-alkyl-9-hydroxy-9,10-dihydropyrene-1-carboxamides in 63–74% yield. Trifluoroacetic acid promoted dehydration of these compounds gave 10-alkyl derivatives of the starting amide in 79–89% yield. The minor products of this reaction were deamidated compounds, 4-alkyl-2,7-di-tert-butylpyrenes.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorWrona-Piotrowicz, Anna
dc.contributor.authorCiechańska, Magdalena
dc.contributor.authorZakrzewski, Janusz
dc.contributor.authorMakal, Anna
dc.date.accessioned2024-01-24T15:41:06Z
dc.date.available2024-01-24T15:41:06Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number20
dc.description.volume83
dc.identifier.doi10.1021/ACS.JOC.8B01024
dc.identifier.issn0022-3263
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/100453
dc.identifier.weblinkhttps://pubs.acs.org/doi/10.1021/acs.joc.8b01024
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofJournal of Organic Chemistry
dc.relation.pages12793-12797
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enN,2,7-tri-tert-butylpyrene-1-carboxamide
dc.subject.enTrifluoroacetic acid
dc.subject.enBuLi
dc.subject.enpyrene
dc.subject.enDirected metalation
dc.subject.enK-region
dc.titleAlkylation of the K-Region in a Sterically Hindered Pyrene Carboxamide via Directed Reaction with Alkyllithiums under Air
dc.typeJournalArticle
dspace.entity.typePublication