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Cognitive impairment in patients with rheumatoid arthritis: A systematic review and meta-analysis

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dc.abstract.enObjective An increasing number of studies have demonstrated cognitive impairment in patients with rheumatoid arthritis (RA). The literature indicates many factors play an important role in this clinical problem, such as the severity of depressive symptoms and the treatment used. The aim of this study was to systematically review studies comparing cognitive functioning between healthy participants and RA patients and to determine both the severity and potential moderators of cognitive impairment. Methods For this purpose, 16 studies that fulfilled all selection criteria were carefully selected. Altogether, 921 patients with RA (812 women and 109 men) and 700 controls participated in these studies. Due to the inability to perform a network meta-analysis, it was decided to determine the effect sizes for studies which used the same measurement methods. Results The analysis demonstrated greater impairment of cognitive functioning in patients with RA than in healthy controls, with effect sizes ranging from small to large, depending on the assessment method used in the study. Conclusions The study pinpoints potential biases, lack of replication, and inconsistencies in reporting data as possible confounding factors and suggests further recommendations for assessment methods, research directions and clinical implications. Clinical trial registration Not applicable.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorWytrychiewicz, Kinga
dc.contributor.authorJanowski, Konrad
dc.contributor.authorPankowski, Daniel
dc.contributor.authorPisula, Ewa
dc.date.accessioned2024-01-24T19:31:01Z
dc.date.available2024-01-24T19:31:01Z
dc.date.issued2022
dc.description.financePublikacja bezkosztowa
dc.description.volume89
dc.identifier.doi10.1016/J.JBSPIN.2021.105298
dc.identifier.issn1297-319X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/103205
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S1297319X21001718
dc.languageeng
dc.pbn.affiliationpsychology
dc.relation.ispartofJoint Bone Spine
dc.relation.pagesNumer artykułu: 105298
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enArthritis
dc.subject.enRheumatoid
dc.subject.enAutoimmune diseases
dc.subject.enPsychology
dc.titleCognitive impairment in patients with rheumatoid arthritis: A systematic review and meta-analysis
dc.typeJournalArticle
dspace.entity.typePublication