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Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates

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dc.abstract.enThe incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl analogs of monastrol-the first low molecular weight kinesin spindle protein (KSP) inhibitor. The obtained compounds showed low micromolar antiproliferative activity towards a panel of sensitive and ABC-overexpressing cancer cells. Most cytotoxic compounds exhibited also higher KSP modulatory activity and ability for ROS generation compared to monastrol. The increased bioactivity of the studied compounds can be attributed to the presence of the ferrocenyl group
dc.affiliationUniwersytet Warszawski
dc.contributor.authorPlażuk, Damian
dc.contributor.authorRychlik, Błażej
dc.contributor.authorHartinger, Christian G.
dc.contributor.authorReynisson, Jóhannes
dc.contributor.authorArabshahi, Homayon J.
dc.contributor.authorEurtivong, Chatchakorn
dc.contributor.authorPawlędzio, Sylwia
dc.contributor.authorMakal, Anna
dc.contributor.authorBłauż, Andrzej
dc.contributor.authorKowalczyk, Karolina
dc.contributor.authorWieczorek-Błauż, Anna
dc.date.accessioned2024-01-25T03:57:11Z
dc.date.available2024-01-25T03:57:11Z
dc.date.issued2022
dc.description.financePublikacja bezkosztowa
dc.description.number2
dc.description.volume51
dc.identifier.doi10.1039/D1DT03553C
dc.identifier.issn1477-9226
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/109042
dc.identifier.weblinkhttp://pubs.rsc.org/en/content/articlepdf/2022/DT/D1DT03553C
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofDalton Transactions
dc.relation.pages491-508
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleImpact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates
dc.typeJournalArticle
dspace.entity.typePublication