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Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism

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dc.abstract.enIn eukaryotes, almost all RNA species are processed at their 3' ends and most mRNAs are polyadenylated in the nucleus by canonical poly(A) polymerases. In recent years, several terminal nucleotidyl transferases (TENTs) including non-canonical poly(A) polymerases (ncPAPs) and terminal uridyl transferases (TUTases) have been discovered. In contrast to canonical polymerases, TENTs' functions are more diverse; some, especially TUTases, induce RNA decay while others, such as cytoplasmic ncPAPs, activate translationally dormant deadenylated mRNAs. The mammalian genome encodes 11 different TENTs. This review summarizes the current knowledge about the functions and mechanisms of action of these enzymes.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGewartowska, Olga
dc.contributor.authorDziembowski, Andrzej
dc.contributor.authorWarkocki, Zbigniew
dc.contributor.authorMROCZEK, SEWERYN
dc.contributor.authorLIUDKOVSKA, VLADYSLAVA
dc.date.accessioned2024-01-26T09:43:27Z
dc.date.available2024-01-26T09:43:27Z
dc.date.issued2018
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.numberSI1762
dc.description.versionFINAL_PUBLISHED
dc.description.volume373
dc.identifier.doi10.1098/RSTB.2018.0162
dc.identifier.issn0962-8436
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121703
dc.identifier.weblinkhttps://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2018.0162
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofPhilosophical Transactions of the Royal Society B: Biological Sciences
dc.relation.pages20180162
dc.rightsCC-BY-ND
dc.sciencecloudnosend
dc.subject.enTENT
dc.subject.ennon-canonical polyadenylation
dc.subject.enRNA uridylation
dc.subject.enTUTase
dc.subject.enRNA stability
dc.subject.enRNA metabolism
dc.titleTerminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism
dc.typeJournalArticle
dspace.entity.typePublication