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Genome structure of the opportunistic pathogen Paracoccus yeei (Alphaproteobacteria) and identification of putative virulence factors

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cris.lastimport.scopus2024-02-12T19:31:01Z
dc.abstract.enBacteria of the genus Paracoccus are common components of the microbiomes of many naturally- and anthropogenically shaped environments. One species, Paracoccus yeei, is unique within the genus because it is associated with opportunistic human infections. Therefore, strains of P. yeei may serve as an interesting model to study the transition from a saprophytic to a pathogenic lifestyle in environmental bacteria. Unfortunately, knowledge concerning the biology, genetics and genomic content of P. yeei is fragmentary; also the mechanisms of pathogenicity of this bacterium remain unclear. In this study we provide the first insight into the genome composition and metabolic potential of a clinical isolate, P. yeei CCUG 32053. This strain has a multipartite genome (4,632,079 bp) composed of a circular chromosome plus eight extrachromosomal replicons pYEE1-8: 3 chromids and 5 plasmids, with a total size of 1,247,173 bp. The genome has been significantly shaped by the acquisition of genomic islands, prophages (Myoviridae and Siphoviridae phage families) and numerous insertion sequences (ISs) representing seven IS families. Detailed comparative analysis with other complete genomic sequences of Paracoccus spp. (including P. yeei FDAARGOS_252 and TT13, as well as non-pathogenic strains of other species in this genus) enabled us to identify P. yeei species-specific genes and to predict putative determinants of virulence. This is the first attempt to identify pathoadaptive genetic information of P. yeei and to estimate the role of the mobilome in the evolution of pathogenicity in this species.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSzuplewska, Magdalena
dc.contributor.authorPawłot, Aleksandra
dc.contributor.authorChmielowska, Cora
dc.contributor.authorSentkowska, Dorota
dc.contributor.authorCzarnecki, Jakub
dc.contributor.authorBartosik, Dariusz
dc.contributor.authorLasek, Robert
dc.contributor.authorDecewicz, Przemysław
dc.date.accessioned2024-01-25T02:05:36Z
dc.date.available2024-01-25T02:05:36Z
dc.date.copyright2018-10-25
dc.date.issued2018
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.versionFINAL_PUBLISHED
dc.identifier.doi10.3389/FMICB.2018.02553
dc.identifier.issn1664-302X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/107844
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofFrontiers in Microbiology
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enParacoccus yeei opportunistic pathogen virulence factors mobilome chromids plasmids genomic islands evolution of pathogenic bacteria
dc.titleGenome structure of the opportunistic pathogen Paracoccus yeei (Alphaproteobacteria) and identification of putative virulence factors
dc.typeJournalArticle
dspace.entity.typePublication