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Nanoconjugates of ferrocene and carbon-encapsulated iron nanoparticles as sensing platforms for voltammetric determination of ceruloplasmin in blood

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cris.lastimport.scopus2024-02-12T20:01:09Z
dc.abstract.enThe nanoparticles comprising of iron core and carbon shell were decorated with ferrocene derivatives: ferrocene ecarboxaldehyde(Fc-1) and ferrocene ecarboxaldehyde oxime (Fc-2). A microdrop of suspension of the nanoconjugatewas placed on a glassy-carbon electrode to prepare the recognition/sensing layer. Drying and purification of the sensing layer resulted in a well-defined and stable square-wave voltammogram of the ferrocene moiety. The height of the voltammetric peak increased in the presence of ceruloplasmin. That increase was linearly dependent on the logarithmic concentration of ceruloplasmin in blood. The applied external magnetic field was a factor which yielded better sensitivity and repeatability of the sensor response. The linearity of sensor response was found to be between 0.001 and 10 μg dL−1 and 0.05–10 μg dL−1 for both nanoconjugates: Fe@C-Fc-1 and Fe@C-Fc-2, in the presence and absence of the magnet, respectively. The obtained detection limit (LOD) for Fe@C-Fc-1 was found to be 0.60 and 0.10 μg dL−1 in the absence and presence of magnetic field, respectively, whilst for Fe@C-Fc-2 was 0.4 and 0.07 μg dL−1 in the absence and presence of a magnet, respectively. The proposed method is selective because the presence of common antioxidants in blood did not interfere significantly with the determination of the concentration of ceruloplasmin.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBystrzejewski, Michał
dc.contributor.authorKaszuwara, Waldemar
dc.contributor.authorStojek, Zbigniew
dc.contributor.authorNowicka, Anna
dc.contributor.authorKasprzak, Artur
dc.contributor.authorPopławska, Magdalena
dc.contributor.authorSęk, Jakub
dc.date.accessioned2024-01-25T13:23:53Z
dc.date.available2024-01-25T13:23:53Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.volume102
dc.identifier.doi10.1016/J.BIOS.2017.11.060
dc.identifier.issn0956-5663
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/113287
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofBiosensors and Bioelectronics
dc.relation.pages490-496
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enNanoconjugates
dc.subject.enFerrocene
dc.subject.enCarbon-encapsulated iron nanoparticles
dc.subject.enCeruloplasmin
dc.subject.enVoltammetry
dc.subject.enBlood analysis
dc.titleNanoconjugates of ferrocene and carbon-encapsulated iron nanoparticles as sensing platforms for voltammetric determination of ceruloplasmin in blood
dc.typeJournalArticle
dspace.entity.typePublication