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Molecular switches in GPCRs

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cris.lastimport.scopus2024-02-12T20:01:25Z
dc.abstract.enMolecular switches in GPCRs enable passing the signal from the agonist binding site, usually located close to the extracellular surface, to the intracellular part of the receptor. The switches are usually associated with conserved structural motifs on transmembrane helices (TMs), and they are accompanied by adjacent residues which provide the signal to the central residue in the toggle switch. In case of locks being the molecular switches, they are breaking (permanently or temporarily) upon agonist binding. Cascade action of switches is correlated with influx of water molecules to form a pathway linking both sides of the receptor. The switches remove the hydrophobic barriers and facilitate water movement while water molecules help to rearrange the hydrogen bond network inside the receptor.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorFilipek, Sławomir
dc.date.accessioned2024-01-25T12:53:34Z
dc.date.available2024-01-25T12:53:34Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.volume55
dc.identifier.doi10.1016/J.SBI.2019.03.017
dc.identifier.issn0959-440X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/112881
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofCurrent Opinion in Structural Biology
dc.relation.pages114-120
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleMolecular switches in GPCRs
dc.typeJournalArticle
dspace.entity.typePublication