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Effect of Structural Factors on Release Profiles of Camptothecin From Block Copolymer Conjugates With High Load of Drug

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dc.abstract.enThe aim of the present work was the synthesis and study the kinetics and profiles of camptothecin (CPT) release form block co- and ter-polymer conjugates comprising polylactide (PLA) segments and CPT moieties, structurally diverse by degrees of branching, content of d-PLA units and poly(ethylene glycol) methyl ether methacrylate (PEGMA). Six PLA, non-toxic macroinitiators (MIs), terminated with α-bromoester were synthesized. MIs were subjected to polymerization of CPT methacrylic derivative (CPTMA) with PEGMA at various ratios. The average contents of CPT from elemental analysis, NMR and UV-GPC were approximate to each other. The number of CPT molecules and PEGMA units was in the range of 9–195 and 0–280 per conjugate, respectively. PEGMA units plasticized PLA causing increase of its crystallinity, whereas 7% and more of d-PLA caused material amorphous. PEGMA units decreased thermal stability of conjugates, however it compatibillized the separated phases of PLA and PCPTMA, based on AFM. In vitro release rate of CPT from linear PLA conjugates deposited on injection-molded PLA bars increased by introduction of PEGMA units with zero-order kinetics and Korsmeyer–Peppas model indicating the super case II transport. Branched conjugates revealed some burst release and then the release was rather of first-order-kinetics with respect to CPT with non-Fickian transport.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorStrawski, Marcin
dc.contributor.authorKowalczyk, Sebastian
dc.contributor.authorPlichta, Andrzej
dc.contributor.authorSobczak, Marcin
dc.contributor.authorOlędzka, Ewa
dc.date.accessioned2024-01-24T22:31:04Z
dc.date.available2024-01-24T22:31:04Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number1-2
dc.description.volume538
dc.identifier.doi10.1016/J.IJPHARM.2018.01.022
dc.identifier.issn0378-5173
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/105832
dc.identifier.weblinkhttp://www.journals.elsevier.com/
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.pages231-242
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enBlock copolymer conjugates
dc.subject.enCamptothecin
dc.subject.enPolylactide
dc.subject.enAtom transfer radical polymerization
dc.subject.enPEG methacrylate
dc.subject.enDrug release kinetics models
dc.titleEffect of Structural Factors on Release Profiles of Camptothecin From Block Copolymer Conjugates With High Load of Drug
dc.typeJournalArticle
dspace.entity.typePublication