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Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

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cris.lastimport.scopus2024-02-12T19:31:21Z
dc.abstract.enIron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin®), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such nanoparticles to the specified tumor tissues. Systematic studies of Ho3+-doped bioconjugates were carried out as a preliminary step for future replacement of 'cold' Ho with 166Ho radionuclide, emitting 'soft' beta(-) radiation for possible targeted radionuclide therapy. Physicochemical properties of the obtained bioconjugates were subsequently tested for use in magnetic hyperthermia, considered as an effective, low-invasiveness anticancer therapy. With such a system we expect to achieve both: active targeting and multimodal action by simultaneous internal and localized irradiation and magnetic hyperthermia of specific cancers.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorPękała, Marek
dc.contributor.authorOsial, Magdalena
dc.contributor.authorŻuk, Michał
dc.contributor.authorGawęda, Weronika
dc.contributor.authorKrysiński, Paweł
dc.contributor.authorBilewicz, Aleksander
dc.date.accessioned2024-01-25T04:59:25Z
dc.date.available2024-01-25T04:59:25Z
dc.date.copyright2020-02-08
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financeŚrodki finansowe przyznane na realizację projektu w zakresie badań naukowych lub prac rozwojowych
dc.description.number2
dc.description.versionFINAL_PUBLISHED
dc.description.volume10
dc.identifier.doi10.3390/NANO10020288
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/110867
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofNanomaterials
dc.relation.pages288
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.ensuperparamagnetc iron oxide nanoparticles
dc.subject.enSPIONs
dc.subject.entrastuzumab
dc.subject.enmagnetic hyperthermia
dc.subject.enantitumor therapy
dc.titleLanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia
dc.typeJournalArticle
dspace.entity.typePublication