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Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease.

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cris.lastimport.scopus2024-02-12T19:53:33Z
dc.abstract.enPurpose: Perivascular release of inflammatory mediators may accelerate coronary lesion formation and contribute to plaque instability. Accordingly, we compared gene expression in pericoronary adipose tissue (PCAT) in patients with advanced coronary artery disease (CAD) and non-CAD controls . Patients and Methods: PCAT samples were collected during coronary bypass grafting from CAD patients (n = 21) and controls undergoing valve replacement surgery, with CAD excluded by coronary angiography (n = 19). Gene expression was measured by GeneChipTM Human Transcriptome Array 2.0. Obtained list of 1348 transcripts (2.0%) that passed the filter criteria was further analyzed by Ingenuity Pathway Analysis software, identifying 735 unique differentially expressed genes (DEGs). Results: Among the CAD patients, 416 (30.9%) transcripts were upregulated, and 932 (69.1%) were downregulated, compared to controls. The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV). Among the top upstream regulators, we identified molecules that have proinflammatory and atherosclerotic features (High Mobility Group Box 2 (HMGB2), platelet-derived growth platelet (PDGF) and evolutionarily conserved signaling intermediate in Toll pathways (ESCIT)). The activated pathway related to DEGs consisted of molecules with well-established role in the pathogenesis of atherosclerosis (TFPI, plasminogen activator, plasminogen activator, urokinase receptor (PLAUR), thrombomodulin). Moreover, we showed that 22 of the altered genes form a proatherogenic network. Conclusion: Altered gene expression in PCAT of CAD patients, with genes upregulation and activation of pathway involved in inflammation and atherosclerosis, may be involved in CAD development and progression.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorMazurek, Tomasz
dc.contributor.authorWilimski, Radosław
dc.contributor.authorKonwerski, Michał
dc.contributor.authorHendzel, Piotr
dc.contributor.authorCzub, Paweł
dc.contributor.authorPol, Aleksandra Gąsecka-Van Der
dc.contributor.authorOpolski, Grzegorz
dc.contributor.authorArendarczyk, Adam
dc.contributor.authorFilipiak, Krzysztof
dc.contributor.authorIwanicka-Nowicka, Roksana
dc.contributor.authorGromadka, Agnieszka
dc.contributor.authorKoblowska, Marta
dc.contributor.authorZielenkiewicz, Piotr
dc.date.accessioned2024-01-24T16:57:47Z
dc.date.available2024-01-24T16:57:47Z
dc.date.copyright2021-10-20
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.versionFINAL_PUBLISHED
dc.description.volume2021
dc.identifier.doi10.2147/JIR.S326769
dc.identifier.issn1178-7031
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/101268
dc.identifier.weblinkhttps://www.dovepress.com/atherosclerosis-pathways-are-activated-in-pericoronary-adipose-tissue--peer-reviewed-fulltext-article-JIR
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofJournal of Inflammation Research
dc.relation.pages5419-5431
dc.rightsCC-BY-NC
dc.sciencecloudnosend
dc.subject.enadipose tissue,
dc.subject.eninflammation,
dc.subject.engene expression,
dc.subject.enatherosclerosis
dc.titleAtherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease.
dc.typeJournalArticle
dspace.entity.typePublication