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Muscular Contribution to Adolescent Idiopathic Scoliosis from the Perspective of Stem Cell-Based Regenerative Medicine

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cris.lastimport.scopus2024-02-12T19:53:38Z
dc.abstract.enAdolescent idiopathic scoliosis (AIS) is a relatively frequent disease within a range 0.5%-5.0% of population, with higher frequency in females. While a resultant spinal deformity is usually medically benign condition, it produces far going psychosocial consequences, which warrant attention. The etiology of AIS is unknown and current therapeutic approaches are symptomatic only, and frequently inconvenient or invasive. Muscular contribution to AIS is widely recognized, although it did not translate to clinical routine as yet. Muscle asymmetry has been documented by pathological examinations as well as systemic muscle disorders frequently leading to scoliosis. It has been also reported numerous genetic, metabolic and radiological alterations in patients with AIS, which are linked to muscular and neuromuscular aspects. Therefore, muscles might be considered an attractive and still insufficiently exploited therapeutic target for AIS. Stem cell-based regenerative medicine is rapidly gaining momentum based on the tremendous progress in understanding of developmental biology. It comes also with a toolbox of various stem cells such as satellite cells or mesenchymal stem cells, which could be transplanted; also, the knowledge acquired in research on regenerative medicine can be applied to manipulation of endogenous stem cells to obtain desired therapeutic goals. Importantly, paravertebral muscles are located relatively superficially; therefore, they can be an easy target for minimally invasive approaches to treatment of AIS. It comes in pair with a fast progress in image guidance, which allows for precise delivery of therapeutic agents, including stem cells to various organs such as brain, muscles, and others. Summing up, it seems that there is a link between AIS, muscles, and stem cells, which might be worth of further investigations with a long-term goal of setting foundations for eventual bench-to-bedside translation.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKalkowski, Łukasz
dc.contributor.authorKowalski, Kamil
dc.contributor.authorKowalczyk, Paweł
dc.contributor.authorBrzóska-Wójtowicz, Edyta
dc.contributor.authorMichalski, Paweł
dc.contributor.authorCiemerych-Litwinienko, Maria
dc.contributor.authorJanowski, Mirosław
dc.contributor.authorWalczak, Piotr
dc.contributor.authorMierzejewski, Bartosz
dc.date.accessioned2024-01-25T13:18:22Z
dc.date.available2024-01-25T13:18:22Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.number16
dc.description.volume28
dc.identifier.doi10.1089/SCD.2019.0073
dc.identifier.issn1547-3287
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/113165
dc.identifier.weblinkhttps://www.liebertpub.com/doi/abs/10.1089/scd.2019.0073?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=scd
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofStem Cells and Development
dc.relation.pages1059-1077
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enscoliosis
dc.subject.enmuscles
dc.subject.enstem cells
dc.subject.enregenerative medicine
dc.subject.enneuromuscular
dc.titleMuscular Contribution to Adolescent Idiopathic Scoliosis from the Perspective of Stem Cell-Based Regenerative Medicine
dc.typeJournalArticle
dspace.entity.typePublication