Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BY - Uznanie autorstwaApplications of Bacterial Degrons and Degraders — Toward Targeted Protein Degradation in Bacteria
| dc.abstract.en | A repertoire of proteolysis-targeting signals known as degrons is a necessary component of protein homeostasis in every living cell. In bacteria, degrons can be used in place of chemical genetics approaches to interrogate and control protein function. Here, we provide a comprehensive review of synthetic applications of degrons in targeted proteolysis in bacteria. We describe recent advances ranging from large screens employing tunable degradation systems and orthogonal degrons, to sophisticated tools and sensors for imaging. Based on the success of proteolysistargeting chimeras as an emerging paradigm in cancer drug discovery, we discuss perspectives on using bacterial degraders for studying protein function and as novel antimicrobials. |
| dc.affiliation | Uniwersytet Warszawski |
| dc.contributor.author | Izert, Matylda |
| dc.contributor.author | Klimecka, Maria |
| dc.contributor.author | Górna, Maria |
| dc.date.accessioned | 2024-01-24T16:44:15Z |
| dc.date.available | 2024-01-24T16:44:15Z |
| dc.date.copyright | 2021-05-07 |
| dc.date.issued | 2021 |
| dc.description.accesstime | AT_PUBLICATION |
| dc.description.finance | Środki finansowe przyznane na realizację projektu w zakresie badań naukowych lub prac rozwojowych |
| dc.description.version | FINAL_PUBLISHED |
| dc.description.volume | 8 |
| dc.identifier.doi | 10.3389/FMOLB.2021.669762 |
| dc.identifier.uri | https://repozytorium.uw.edu.pl//handle/item/100981 |
| dc.identifier.weblink | https://www.frontiersin.org/articles/10.3389/fmolb.2021.669762/full |
| dc.language | eng |
| dc.pbn.affiliation | biological sciences |
| dc.relation.ispartof | Frontiers in Molecular Biosciences |
| dc.relation.pages | art.no. 669762 |
| dc.rights | CC-BY |
| dc.sciencecloud | nosend |
| dc.subject.en | degron |
| dc.subject.en | degradation signal |
| dc.subject.en | degrader |
| dc.subject.en | targeted protein degradation |
| dc.subject.en | bacterial protease |
| dc.subject.en | proteolysistargeting chimeras |
| dc.subject.en | induced degradation |
| dc.title | Applications of Bacterial Degrons and Degraders — Toward Targeted Protein Degradation in Bacteria |
| dc.type | JournalArticle |
| dspace.entity.type | Publication |