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Small and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine

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dc.abstract.enCatalysis is an essential feature of living systems biochemistry, and probably, it played a key role in primordial times, helping to produce more complex molecules from simple ones. However, enzymes, the biocatalysts par excellence, were not available in such an ancient context, and so, instead, small molecule catalysis (organocatalysis) may have occurred. The best candidates for the role of primitive organocatalysts are amino acids and short random peptides, which are believed to have been available in an early period on Earth. In this review, we discuss the occurrence of primordial organocatalysts in the form of peptides, in particular commenting on reports about seryl-histidine dipeptide, which have recently been investigated. Starting from this specific case, we also mention a peptide fragment condensation scenario, as well as other potential roles of peptides in primordial times. The review actually aims to stimulate further investigation on an unexplored field of research, namely one that specifically looks at the catalytic activity of small random peptides with respect to reactions relevant to prebiotic chemistry and early chemical evolution.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorPolticelli, Fabio
dc.contributor.authorGasperi, Tecla
dc.contributor.authorAdamala, Katarzyna
dc.contributor.authorStano, Pasquale
dc.contributor.authorWieczorek, Rafał
dc.date.accessioned2024-01-26T07:49:26Z
dc.date.available2024-01-26T07:49:26Z
dc.date.copyright2017-04-09
dc.date.issued2017
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number2
dc.description.versionFINAL_PUBLISHED
dc.description.volume7
dc.identifier.doi10.3390/LIFE7020019
dc.identifier.issn0024-3019
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/120027
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofLife
dc.relation.pagesart.no.19
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enfragment condensation
dc.subject.enorganocatalysis
dc.subject.enpeptide bond formation
dc.subject.enphosphodiester bond formation
dc.subject.enSer-His
dc.subject.ensmall peptides
dc.titleSmall and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine
dc.typeJournalArticle
dspace.entity.typePublication