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Properties of Omp2a-Based Supported Lipid Bilayers: Comparison with Polymeric Bioinspired Membranes

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cris.lastimport.scopus2024-02-12T20:02:36Z
dc.abstract.enOmp2a β-barrel outer membrane protein has been reconstituted into supported lipid bilayers (SLBs) to compare the nanomechanical properties (elastic modulus, adhesion forces, and deformation) and functionality of the resulting bioinspired system with those of Omp2a-based polymeric nanomembranes (NMs). Protein reconstitution into lipid bilayers has been performed using different strategies, the most successful one consisting of a detergent-mediated process into preformed liposomes. The elastic modulus obtained for the lipid bilayer and Omp2a are ∼19 and 10.5 ± 1.7 MPa, respectively. Accordingly, the protein is softer than the lipid bilayer, whereas the latter exhibits less mechanical strength than polymeric NMs. Besides, the function of Omp2a in the SLB is similar to that observed for Omp2a-based polymeric NMs. Results open the door to hybrid bioinspired substrates based on the integration of Omp2a-proteoliposomes and nanoperforated polymeric freestanding NMs.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorPawłowski, Jan
dc.contributor.authorPuiggalí-Jou, Anna
dc.contributor.authorSęk, Sławomir
dc.contributor.authorMichaux, Catherine
dc.contributor.authorAlemán, Carlos
dc.contributor.authorPerpète, Eric A.
dc.contributor.authorValle, Luis J. del
dc.date.accessioned2024-01-25T18:11:31Z
dc.date.available2024-01-25T18:11:31Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number8
dc.description.volume3
dc.identifier.doi10.1021/ACSOMEGA.8B00913
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/117246
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofACS Omega
dc.relation.pages9003-9019
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleProperties of Omp2a-Based Supported Lipid Bilayers: Comparison with Polymeric Bioinspired Membranes
dc.typeJournalArticle
dspace.entity.typePublication