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Degradable, thermo-, pH- and redox-sensitive hydrogel microcapsules for burst and sustained release of drugs

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dc.abstract.enPolymer microcapsules offer a possibility of storing increased amounts of drugs. Appropriate design and composition of the microcapsules allow tuning of the drug-release process. In this paper, we report on synthesis of hydrogel microcapsules sensitive to temperature and pH and degradable by glutathione and hydrogen peroxide. Microcapsules were based on thermo-responsive poly(N-isopropylacrylamide) and degradable cystine crosslinker, and were synthesized by applying precipitation polymerization. Such way of polymerization was appropriately modified to limit the crosslinking in the microcapsule center. This led to a possibility of washing out the pNIPA core at room temperature and the formation of a capsule. Microcapsules revealed rather high drug-loading capacity of ca. 17%. The degradation of the microcapsules by the reducing agent (GSH) and the oxidizing agent (H2O2) was confirmed by using the DLS, UV-Vis, SEM and TEM techniques. Depending on pH and concentration of the reducing/oxidizing agents a fast or slow degradation of the microcapsules and a burst or long-term release of doxorubicin (DOX) were observed. The DOX loaded microcapsules appeared to be cytotoxic against A2780 cancer cells similarly to DOX alone, while unloaded microcapsules did not inhibit proliferation of the cells.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorDrabczyk, Kinga
dc.contributor.authorWałęka, Ewelina
dc.contributor.authorKarbarz, Marcin
dc.contributor.authorStojek, Zbigniew
dc.contributor.authorRomański, Jan
dc.contributor.authorMaćkiewicz, Marcin
dc.date.accessioned2024-01-24T21:19:26Z
dc.date.available2024-01-24T21:19:26Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.volume569
dc.identifier.doi10.1016/J.IJPHARM.2019.118589
dc.identifier.issn0378-5173
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/104465
dc.identifier.weblinkhttps://repo.pw.edu.pl/info/article/WUT3f9bff4a265e4987b02d2b4944128228/
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.pages118589_1-118589_11
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enCystine
dc.subject.enDegradation
dc.subject.enDisulfide bridges
dc.subject.enDrug delivery
dc.subject.enGlutathione
dc.subject.enMicrocapsule
dc.subject.enN-isopropylacrylamide
dc.subject.enROS
dc.subject.enSulfone
dc.subject.enSulfoxide
dc.subject.enThioethers
dc.subject.enpH
dc.titleDegradable, thermo-, pH- and redox-sensitive hydrogel microcapsules for burst and sustained release of drugs
dc.typeJournalArticle
dspace.entity.typePublication