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Antibacterial peptide nucleic acids—facts and perspectives.

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dc.abstract.enAntibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century. This fact creates an urgent need for new and effective antimicrobials. The common strategies for antibiotic discovery are based on either modifying existing antibiotics or screening compound libraries, but these strategies have not been successful in recent decades. An alternative approach could be to use gene-specific oligonucleotides, such as peptide nucleic acid (PNA) oligomers, that can specifically target any single pathogen. This approach broadens the range of potential targets to any gene with a known sequence in any bacterium, and could significantly reduce the time required to discover new antimicrobials or their redesign, if resistance arises. We review the potential of PNA as an antibacterial molecule. First, we describe the physicochemical properties of PNA and modifications of the PNA backbone and nucleobases. Second, we review the carriers used to transport PNA to bacterial cells. Furthermore, we discuss the PNA targets in antibacterial studies focusing on antisense PNA targeting bacterial mRNA and rRNA.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorRównicki, Marcin
dc.contributor.authorMiszkiewicz, Joanna
dc.contributor.authorTrylska, Joanna
dc.contributor.authorWojciechowska, Monika
dc.contributor.authorMieczkowski, Adam
dc.date.accessioned2024-01-24T16:40:05Z
dc.date.available2024-01-24T16:40:05Z
dc.date.copyright2020-01-28
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number3
dc.description.versionFINAL_AUTHOR
dc.description.volume25
dc.identifier.doi10.3390/MOLECULES25030559
dc.identifier.issn1420-3049
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/100770
dc.identifier.weblinkhttps://www.mdpi.com/1420-3049/25/3/559
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofMolecules
dc.relation.pages559
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enoligonucleotides
dc.subject.enpeptide nucleic acid (PNA)
dc.subject.enantibacterials
dc.subject.enRNA
dc.subject.enPNA transporters
dc.subject.enconjugates
dc.subject.enbacterial resistance
dc.titleAntibacterial peptide nucleic acids—facts and perspectives.
dc.typeJournalArticle
dspace.entity.typePublication