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Lipidic Cubic-Phase Nanoparticles (Cubosomes) Loaded with Doxorubicin and Labeled with 177Lu as a Potential Tool for Combined Chemo and Internal Radiotherapy for Cancers

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dc.abstract.enLipid liquid-crystalline nanoparticles (cubosomes) were used for the first time as a dual-modality drug delivery ystem for internal radiotherapy combined with chemotherapy. Monoolein (GMO)-based cubosomes were prepared by ading the anticancer drug, doxorubicin and a commonly used radionuclide, low-energy beta (β−)-emitter,177 Lu. The radionuclide was complexed with a long chain derivative of DOTAGA (DOTAGA-OA). The DOTAGA headgroup of the chelator was exposed to the aqueous channels of the cubosomes, while, concerning OA, the hydrophobic tail was embedded in the nonpolar region of the lipid bilayer matrix, placing the radioactive dopant in a stable manner inside the cubosome. The cubosomes containing doxorubicin and the radionuclide complex increased the cytotoxicity easured by the viability of the treated HeLa cells compared with the effect of single-drug cubosomes containing either the DOX DOTAGA-OA or DOTAGA-OA-177 Lu complex. Multifunctional lipidic nanoparticles encapsulating the chemotherapeutic agent together with appropriately complexed (β−) radionuclide are proposed as a potential strategy for effective local therapy of various cancers.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBilewicz, Renata
dc.contributor.authorCytryniak, Adrianna
dc.contributor.authorNazaruk, Ewa
dc.contributor.authorGórzyńska, Emilia
dc.contributor.authorŻelechowska-Matysiak, Kinga
dc.contributor.authorMAMES, Adam
dc.contributor.authorWalczak, Rafał
dc.contributor.authorMajkowska-Pilip, Agnieszka
dc.contributor.authorBilewicz, Aleksander
dc.date.accessioned2024-01-25T05:11:56Z
dc.date.available2024-01-25T05:11:56Z
dc.date.copyright2020-11-16
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number11
dc.description.versionFINAL_PUBLISHED
dc.description.volume10
dc.identifier.doi10.3390/NANO10112272
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/111313
dc.identifier.weblinkhttps://www.mdpi.com/2079-4991/10/11/2272/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofNanomaterials
dc.relation.pages2272
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.en177 Lu
dc.subject.enChemotherapy
dc.subject.enCombined anticancer therapy
dc.subject.enCubosome
dc.subject.enDoxorubicin
dc.subject.enDrug carrier
dc.subject.enRadiotherapy
dc.titleLipidic Cubic-Phase Nanoparticles (Cubosomes) Loaded with Doxorubicin and Labeled with 177Lu as a Potential Tool for Combined Chemo and Internal Radiotherapy for Cancers
dc.typeJournalArticle
dspace.entity.typePublication