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Fragmentation and transferability in Hirshfeld atom refinement

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dc.abstract.enHirshfeld atom refinement (HAR) is one of the most effective methods for obtaining accurate structural parameters for hydrogen atoms from X-ray diffraction data. Unfortunately, it is also relatively computationally expensive, especially for larger molecules due to wavefunction calculations. Here, a fragmentation approach has been tested as a remedy for this problem. It gives an order of magnitude improvement in computation time for larger organic systems and is a few times faster for metal-organic systems at the cost of only minor differences in the calculated structural parameters when compared with the original HAR calculations. Fragmentation was also applied to polymeric and disordered systems where it provides a natural solution to problems that arise when HAR is applied. The concept of fragmentation is closely related to the transferable aspherical atom model (TAAM) and allows insight into possible ways to improve TAAM. Hybrid approaches combining fragmentation with the transfer of atomic densities between chemically similar atoms have been tested. An efficient handling of intermolecular interactions was also introduced for calculations involving fragmentation. When applied in fragHAR (a fragmentation approach for polypeptides) as a replacement for the original approach, it allowed for more efficient calculations. All of the calculations were performed with a locally modified version of Olex2 combined with a development version of discamb2tsc and ORCA. Care was taken to efficiently use the power of multicore processors by simple implementation of load-balancing, which was found to be very important for lowering computational time.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorWoźniak, Krzysztof
dc.contributor.authorWoińska, Magdalena
dc.contributor.authorPawlędzio, Sylwia
dc.contributor.authorChodkiewicz, Michał
dc.date.accessioned2024-01-25T01:15:36Z
dc.date.available2024-01-25T01:15:36Z
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financeŚrodki finansowe, o których mowa w art. 365 pkt. 2 ustawy
dc.description.number2
dc.description.sdgZeroHunger
dc.description.versionFINAL_PUBLISHED
dc.description.volume9
dc.identifier.doi10.1107/S2052252522000690
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/107448
dc.identifier.weblinkhttp://journals.iucr.org/m/issues/2022/02/00/fc5059/fc5059.pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofIUCrJ
dc.relation.pages298-315
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enfragmentation
dc.subject.enHirshfeld atom refinement
dc.subject.enquantum crystallography.
dc.subject.entransferability
dc.titleFragmentation and transferability in Hirshfeld atom refinement
dc.typeJournalArticle
dspace.entity.typePublication