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Evaluation of the influence of diet supplementation with conjugated linoleic acid isomers on elemental composition in the cardio-oncological nutritional programming rat’ model

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cris.lastimport.scopus2024-02-12T19:46:03Z
dc.abstract.enBackground: The ‘developmental origin of health and disease’ (DOHaD) hypothesis assumes that due to the action of some stimuli during fetal life the long-term physiological changes occurs and may affects the risk of various diseases. The main aim of this study was to assess impact of supplementation of maternal’ and early postnatal diet with conjugated linoleic acids (CLA) isomers on selected elements content in hearts of their female offspring with chemically induced breast cancer. Methods: Elemental composition was determined by quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS).Results: The effect of maternal’ diet on the elements content was more pronounced than the progeny diet modifications. Significant correlations among determined elements, especially macroelements, and lipidomic parameters, in the experimental factors dependent manner were observed. It can be concluded that supplementation of maternal and progeny diets with CLA isomers may significantly influence the contents of both macro- and microelements in cardiac tissue of newborns.Conclusion: Our results also indicate, that dynamic and intricate balance among various elements in body may be affected by the lipid dietary supplements also in the pathological state. Utility of cardio-oncological approach in developmental programming study was confirmed.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorCzauderna, Marian
dc.contributor.authorBiałek, Małgorzata
dc.contributor.authorBiałek, Agnieszka
dc.contributor.authorZaworski, Kamil
dc.contributor.authorRuszczyńska, Anna
dc.contributor.authorBulska, Ewa
dc.date.accessioned2024-01-24T23:38:24Z
dc.date.available2024-01-24T23:38:24Z
dc.date.issued2021
dc.description.financePublikacja bezkosztowa
dc.description.volume68
dc.identifier.doi10.1016/J.JTEMB.2021.126816
dc.identifier.issn0946-672X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/106561
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S0946672X21001061?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofJournal of Trace Elements in Medicine and Biology
dc.relation.pages126816
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enConjugated linoleic acid
dc.subject.enBreast cancer
dc.subject.enNutritional programming
dc.subject.enElements
dc.subject.enRats
dc.subject.enHeart
dc.titleEvaluation of the influence of diet supplementation with conjugated linoleic acid isomers on elemental composition in the cardio-oncological nutritional programming rat’ model
dc.typeJournalArticle
dspace.entity.typePublication