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Comprehensive Protocol for the Identification and Characterization of New Psychoactive Substances in the Service of Law Enforcement Agencies

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cris.lastimport.scopus2024-02-12T19:58:47Z
dc.abstract.enA non-routine, comprehensive protocol for characterization of emerging new psychoactive substances (NPS) including chemical structures, impurities, as well as crystal structures, has been developed to facilitate the work of law enforcement agencies. A set of NPS has been synthesized, identified, and characterized by various analytical methods in order to be used as certified reference standards (CRMs). Seven selected compounds (5-IT, NM-2201, MT-45, AB-CHMINACA, UR-144, 5F-PB-22, and 4-CMC) were synthesized on the laboratory scale, then the process was upscaled to semi-technical. All products were analyzed by electrospray Q/TOF-MS/MS for molecular structure identification. The presence of by-products, as well as metal impurities, arising from the performed syntheses, were characterized by reversed phase liquid chromatography (RP-HPLC) with DAD and Q/TOF-MS detection and inductively-coupled plasma with quadrupole mass spectrometer (ICP-QMS), respectively. Additionally, the crystal structures of UR-144, NM-2201, 5F-PB-22, and 4-CMC have been determined by single-crystal and powder X-ray diffraction.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBulska, Ewa
dc.contributor.authorCyrański, Michał
dc.contributor.authorMichalska-Kacymirow, Magdalena
dc.contributor.authorKośnik, Wioletta
dc.contributor.authorGrela, Karol
dc.contributor.authorDobrowolski, Michał
dc.contributor.authorBachliński, Robert
dc.contributor.authorMałecki, Paweł
dc.date.accessioned2024-01-24T19:52:27Z
dc.date.available2024-01-24T19:52:27Z
dc.date.issued2020
dc.description.financeŚrodki finansowe, o których mowa w art. 365 pkt. 2 ustawy
dc.description.volume8
dc.identifier.doi10.3389/FCHEM.2020.00693
dc.identifier.issn2296-2646
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/103462
dc.identifier.weblinkhttps://www.frontiersin.org/article/10.3389/fchem.2020.00693/full
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofFrontiers in Chemistry
dc.relation.pagesart.no.693
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.ennew psychoactive substance (NPS)
dc.subject.ensynthetic cannabinoid (SC)
dc.subject.enX-ray diffraction
dc.subject.enES Q/TOF MS/MS
dc.subject.enLC-Q/TOF
dc.titleComprehensive Protocol for the Identification and Characterization of New Psychoactive Substances in the Service of Law Enforcement Agencies
dc.typeJournalArticle
dspace.entity.typePublication