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The effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment

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dc.abstract.enSquamous cell carcinoma of the skin is the second most common cutaneous malignancy. Despite various available treatment methods and advances in noninvasive diagnostic techniques, the incidence of metastatic cutaneous squamous cell carcinoma is rising. Deficiency in effective preventive or treatment methods of transformed keratinocytes leads to necessity of searching for new anticancer agents. The present study aims to evaluate the possibility of using wool hydrolysates as such agents. Commercially available compounds such as 5-fluorouracil, ingenol mebutate, diclofenac sodium salt were also used in this study. The process of wool degradation was based on chemical pre-activation and enzymatic digestion of wool. The effect of mentioned compounds on cell viability of squamous carcinoma cell line and healthy keratinocytes was evaluated. The obtained data show a significantly stronger effect of selected wool hydrolysates compared to commercial compounds (p<0.05) on viability of cells. The wool hydrolysates decreased squamous cell carcinoma cells viability by up to 67% comparing to untreated cells. These results indicate bioactive properties of wool hydrolysates, which affect the viability of squamous carcinoma cells and decrease their number. We hypothesize that these agents may be used topically for treatment of transformed keratinocytes in actinic keratosis and invasive squamous skin cancer in humans. © 2017 Damps et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorMisicka-Kęsik, Aleksandra
dc.contributor.authorPuszko, Anna
dc.contributor.authorLaskowska, Anna
dc.contributor.authorKowalkowski, Tomasz
dc.contributor.authorRudnicka, Lidia
dc.contributor.authorBorkowska, Joanna
dc.contributor.authorDamps, Tatsiana
dc.contributor.authorKonop, Marek
dc.contributor.authorSosnowski, Piotr
dc.contributor.authorCzuwara, Joanna
dc.contributor.authorProkopowicz, Monika
dc.contributor.authorRóżycki, Krzysztof
dc.date.accessioned2024-01-26T10:11:47Z
dc.date.available2024-01-26T10:11:47Z
dc.date.copyright2017-08-30
dc.date.issued2017
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number8
dc.description.versionFINAL_PUBLISHED
dc.description.volume12
dc.identifier.doi10.1371/JOURNAL.PONE.0184034
dc.identifier.issn1932-6203
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/122221
dc.identifier.weblinkhttp://journals.plos.org
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofPLoS ONE
dc.relation.pagesart.no. e0184034
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleThe effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment
dc.typeJournalArticle
dspace.entity.typePublication