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(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione—Synthesis and Crystallographic Studies

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cris.lastimport.scopus2024-02-12T19:58:24Z
dc.abstract.en(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione was obtained in a three-step, one-pot synthesis, starting from optically pure(S)-2-piperazine carboxylic acid dihydrochloride. Selective acylation of theβ-nitrogen atom followedby condensation with isatoic anhydride and cyclization with HATU/DIPEA to a seven-memberbenzodiazepine ring, led to the tricyclic benzodiazepine derivative. Crystallographic studies andinitial biological screening were performed for the title compound.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorWilczek, Marcin
dc.contributor.authorTrzybiński, Damian
dc.contributor.authorBieszczad, Bartosz
dc.contributor.authorPSURSKI, MATEUSZ
dc.contributor.authorWoźniak, Krzysztof
dc.contributor.authorMieczkowski, Adam
dc.contributor.authorMroczkowska, Magdalena
dc.contributor.authorBagiński, Maciej
dc.date.accessioned2024-01-25T19:34:28Z
dc.date.available2024-01-25T19:34:28Z
dc.date.issued2017
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number4
dc.description.versionFINAL_PUBLISHED
dc.description.volume2017
dc.identifier.doi10.3390/M964
dc.identifier.issn1422-8599
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/118953
dc.identifier.weblinkhttps://www.mdpi.com/1422-8599/2017/4/M964
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofMolBank
dc.relation.pagesM964
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.en(S)-2-piperazinecarboxylic acid
dc.subject.entricyclic benzodiazepines
dc.subject.enisatoic anhydride
dc.subject.encytotoxicity
dc.title(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione—Synthesis and Crystallographic Studies
dc.typeJournalArticle
dspace.entity.typePublication