Artykuł w czasopiśmie
Brak miniatury
Licencja
Dostęp zamkniętySynthesis of 19-norcalcitriol analogs with pegylated alkylidene chains at C-2.
| dc.abstract.en | The results presented in this paper constitute an extension of our synthetic efforts focused on 19-norvitamin D compounds possessing elongated 2-alkylidene substituents. Based on our previous results, molecular modeling studies, and docking experiments, we selected a novel 19-norcalcitriol analog with long chain at C-2 containing several ether moieties and terminated by 2-(pyridin-2′-yl)ethylamino fragment. It was expected that such structural modification might allow binding of transition metal by the ligand, increase solubility of the formed complexes as well as improve their affinity to the VDR. For comparison, a 19-norcalcitriol analog was also obtained with the terminal hydroxyl group at its pegylated 2-alkylidene substituent. The synthesis of the target vitamin D compounds described in this work was performed using the Wittig-Horner approach. The respective A-ring phosphine oxide was obtained starting from the D-(-)-quinic acid and then coupled with the known Grundmann ketone |
| dc.affiliation | Uniwersytet Warszawski |
| dc.contributor.author | Berkowska, Klaudia |
| dc.contributor.author | Marcinkowska, Ewa |
| dc.contributor.author | Siciński, Rafał |
| dc.contributor.author | Fabisiak, Adrian |
| dc.contributor.author | Brzemiński, Paweł |
| dc.date.accessioned | 2024-01-26T09:26:42Z |
| dc.date.available | 2024-01-26T09:26:42Z |
| dc.date.issued | 2019 |
| dc.description.finance | Nie dotyczy |
| dc.description.volume | 185 |
| dc.identifier.doi | 10.1016/J.JSBMB.2018.09.015 |
| dc.identifier.issn | 0960-0760 |
| dc.identifier.uri | https://repozytorium.uw.edu.pl//handle/item/121300 |
| dc.identifier.weblink | https://doi.org/10.1016/j.jsbmb.2018.09.015 |
| dc.language | eng |
| dc.pbn.affiliation | chemical sciences |
| dc.relation.ispartof | Journal of Steroid Biochemistry and Molecular Biology |
| dc.relation.pages | 251-255 |
| dc.rights | ClosedAccess |
| dc.sciencecloud | nosend |
| dc.subject.en | B-secosteroids |
| dc.subject.en | 19-Norcalcitriol |
| dc.subject.en | Vitamin D receptor |
| dc.subject.en | PEG linker |
| dc.subject.en | Wittig-Horner olefination |
| dc.title | Synthesis of 19-norcalcitriol analogs with pegylated alkylidene chains at C-2. |
| dc.type | JournalArticle |
| dspace.entity.type | Publication |