Rozdział w monografii
Brak miniatury
Licencja
ClosedAccessDostęp zamknięty
 

Modeling Nucleic Acids at the Residue–Level Resolution

Uproszczony widok
cris.lastimport.scopus2024-02-12T19:57:10Z
dc.abstract.enCoarse–grained models and force fields have become useful in the studies of the dynamics and physicochemical properties of nucleic acids. Reduced representations of DNA or RNA allow saving computational cost of a few orders of magnitude in comparison with full–atomistic simulations. In this chapter we describe a few selected coarse–grained models of nucleic acids in which one nucleotide is represented as either one, two or three beads. We present the examples of the models designed to investigate the internal dynamics and temperature-dependent denaturation of nucleic acids, as well as created to predict the tertiary structure of RNA or used for large ribonucleoprotein complexes. We describe how the purpose of the model affects the design of the potential energy function and the choice of the simulation method. We also address the limitations of these models.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorTrylska, Joanna
dc.contributor.authorLeonarski, Filip
dc.date.accessioned2024-01-29T01:50:02Z
dc.date.available2024-01-29T01:50:02Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.identifier.doi10.1007/978-3-319-95843-9_5
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/156027
dc.identifier.weblinkhttp://link.springer.com/content/pdf/10.1007/978-3-319-95843-9_5
dc.languageeng
dc.pbn.affiliationphysical sciences
dc.publisher.ministerialSpringer
dc.relation.bookComputational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes
dc.relation.pages117-161
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleModeling Nucleic Acids at the Residue–Level Resolution
dc.typeMonographChapter
dspace.entity.typePublication