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Contrasting Health Effects of Bacteroidetes and Firmicutes Lies in Their Genomes: Analysis of P450s, Ferredoxins, and Secondary Metabolite Clusters

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cris.lastimport.scopus2024-02-12T19:38:52Z
dc.abstract.enSpecies belonging to the bacterial phyla Bacteroidetes and Firmicutes represent over 90% of the gastrointestinal microbiota. Changes in the ratio of these two bacterial groups were found to have contrasting health effects, including obesity and inflammatory diseases. Despite the availability of many bacterial genomes, comparative genomic studies on the gene pools of these two bacterial groups concerning cytochrome P450 monooxygenases (P450s), ferredoxins, and secondary metabolite biosynthetic gene clusters (smBGCs) are not reported. This study is aimed to address this research gap. The study revealed the presence of diverse sets of P450s, ferredoxins, and smBGCs in their genomes. Bacteroidetes species have the highest number of P450 families, ferredoxin cluster-types, and smBGCs compared to Firmicutes species. Only four P450 families, three ferredoxin cluster types, and five smBGCs are commonly shared between these two bacterial groups. Considering the above facts, we propose that the contrasting effects of these two bacterial groups on the host are partly due to the distinct nature of secondary metabolites produced by these organisms. Thus, the cause of the contrasting health effects of these two bacterial groups lies in their gene pools
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSyed, Khajamohiddin
dc.contributor.authorNelson, David R.
dc.contributor.authorGront, Dominik
dc.contributor.authorPadayachee, Tiara
dc.contributor.authorNkosi, Bridget Valeria Zinhle
dc.date.accessioned2024-01-24T20:47:05Z
dc.date.available2024-01-24T20:47:05Z
dc.date.copyright2022-05-02
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number9
dc.description.versionFINAL_PUBLISHED
dc.description.volume23
dc.identifier.doi10.3390/IJMS23095057
dc.identifier.issn1422-0067
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/103695
dc.identifier.weblinkhttps://www.mdpi.com/1422-0067/23/9/5057/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.pages5057
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enBacteroidetes
dc.subject.enCytochrome P450 monooxygenases
dc.subject.enferredoxins
dc.subject.enFirmicutes
dc.subject.enhuman gut microbiome
dc.subject.enhuman health
dc.subject.ensecondary metabolite gene clusters
dc.titleContrasting Health Effects of Bacteroidetes and Firmicutes Lies in Their Genomes: Analysis of P450s, Ferredoxins, and Secondary Metabolite Clusters
dc.typeJournalArticle
dspace.entity.typePublication