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Upconversion fluorescence imaging of HeLa cells using ROS generating SiO2-coated lanthanide-doped NaYF4 nanoconstructs

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dc.abstract.enInorganic nanomaterials able to generate reactive oxygen species (ROS) are promising components for modern medical applications. Activated by near-infrared light, up-converting beta-NaYF4 doped with Er3+ - Yb3+ and Tm3+- Yb3+ pair ions nanoparticles (UCNPs), have a wide range of applications in biological imaging as compared to traditional reagents excited by ultra-violet or visible light. We analysed the green-red and the blue-red luminescence to explain the mechanism of the upconversion depended on the surface condition. The influence of SiO2 coating on the cytotoxicity of the as-produced UCNPs towards HeLa cancer cells was reported. We demonstrated a possibility of a direct UCNPs application to photodynamic therapy, without need to attach additional molecules to their surface. The presence of Tm3+ - Yb3+ pair ions, thus ROS generation capability, renders the SiO2 shell coated nanoparticles to become potentially useful theranostic agent.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSikora, Bożena
dc.contributor.authorFrontczak-Baniewicz, Małgorzata
dc.contributor.authorPaszkowicz, Wojciech
dc.contributor.authorStępień, Piotr
dc.contributor.authorKamińska, Izabela
dc.contributor.authorSzczepkowski, Jacek
dc.contributor.authorŁapiński, Mariusz
dc.contributor.authorSouza, Paulo Eduardo de
dc.contributor.authorJastrzębski, Włodzimierz
dc.contributor.authorMorais, Paulo C.
dc.contributor.authorElbaum, Danek
dc.contributor.authorVeiga-Souza, Fabiane Hiratsuka
dc.contributor.authorMosiniewicz-Szablewska, Ewa
dc.contributor.authorNunes, Rodrigo Barbosa
dc.contributor.authorWojciechowski, Tomasz
dc.contributor.authorGruzel, Grzegorz
dc.contributor.authorMikulski, Jakub
dc.contributor.authorFronc, Krzysztof
dc.contributor.authorPawlyta, Mirosława
dc.contributor.authorZajdel, Karolina
dc.contributor.authorSienkiewicz, Andrzej
dc.contributor.authorSzewczyk, Maciej
dc.contributor.authorKowalik, Przemysław
dc.contributor.authorMinikayev, Roman
dc.date.accessioned2024-01-26T11:20:18Z
dc.date.available2024-01-26T11:20:18Z
dc.date.copyright2017-06-12
dc.date.issued2017
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number48
dc.description.versionFINAL_PUBLISHED
dc.description.volume7
dc.identifier.doi10.1039/C6RA25383K
dc.identifier.issn2046-2069
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/124276
dc.identifier.weblinkhttps://pubs.rsc.org/en/content/articlelanding/2017/RA/C6RA25383K#!divAbstract
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofRSC Advances
dc.relation.pages30262-30273
dc.rightsCC-BY-NC
dc.sciencecloudnosend
dc.subject.enPHOTODYNAMIC THERAPY
dc.subject.enQUANTUM DOTS
dc.subject.enSILICA NANOPARTICLES
dc.subject.enLAF3 NANOPARTICLES
dc.subject.enMONODISPERSE
dc.subject.enNANOCRYSTALS
dc.subject.enHEXAGONAL-PHASE
dc.subject.enSMALL ANIMALS
dc.subject.enLUMINESCENCE
dc.subject.enEMISSION
dc.subject.enIONS
dc.titleUpconversion fluorescence imaging of HeLa cells using ROS generating SiO2-coated lanthanide-doped NaYF4 nanoconstructs
dc.typeJournalArticle
dspace.entity.typePublication